Treatment Strategy to Improve Long-Term Survival for Hepatocellular Carcinoma Smaller than 5 cm: Major Hepatectomy vs Minor Hepatectomy
Background The extent of hepatectomy for solitary hepatocellular carcinoma (HCC)
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| Veröffentlicht in: | World journal of surgery 2014-09, Vol.38 (9), p.2386-2394 |
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| creator | Wong, Tiffany Cho Lam Cheung, Tan To Chok, Kenneth S. H. Chan, Albert C. Y. Dai, Wing Chiu Chan, See Ching Poon, Ronnie T. P. Lo, Chung Mau |
| description | Background
The extent of hepatectomy for solitary hepatocellular carcinoma (HCC) |
| doi_str_mv | 10.1007/s00268-014-2601-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1552368949</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3394707861</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5581-6cf4a135c7e8bb66520f29d92dbf7aa1b03ebff9677a816c75b202182e99f5bf3</originalsourceid><addsrcrecordid>eNqFkc1uEzEURi1ERUPhAdggS2zYTPHP2B6zoxGlRalYJIil5Zlch4nG42DPBOUNeAyehSero2lRQUKsLF2f79O9Ogi9oOScEqLeJEKYrApCy4JJQovyEZrRkrOCccYfoxnhMv9wyk_R05S2hFAliXyCTllZcSoVnaEfqwh28NAPeDlEO8DmgIeAr_0uhj3gReg3xQqix8sx7tu97bALEV_Bzg6hga4bOxvx3Mam7YO3eOlt10HEw1fbY_HrZ-Pf4hu7vY9AMwR_wPuEbzL_x_AZOnG2S_D87j1Dny_fr-ZXxeLTh-v5u0XRCFHRQjautJSLRkFV11IKRhzTa83WtVPW0ppwqJ3TUilbUdkoUTPCaMVAaydqx8_Q66k3H_hthDQY36bjJbaHMCZDhWBcVrrUGX31F7oNY-zzdkeKCp0hlSk6UU0MKUVwZhdbb-PBUGKOmsykyWRN5qjJlDnz8q55rD2sfyfuvWRAT8D3toPD_xvNl4_Li0uisuKcZVM25Vi_gfhg7X9udAud-a_F</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1551599497</pqid></control><display><type>article</type><title>Treatment Strategy to Improve Long-Term Survival for Hepatocellular Carcinoma Smaller than 5 cm: Major Hepatectomy vs Minor Hepatectomy</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>SpringerLink Journals - AutoHoldings</source><creator>Wong, Tiffany Cho Lam ; Cheung, Tan To ; Chok, Kenneth S. H. ; Chan, Albert C. Y. ; Dai, Wing Chiu ; Chan, See Ching ; Poon, Ronnie T. P. ; Lo, Chung Mau</creator><creatorcontrib>Wong, Tiffany Cho Lam ; Cheung, Tan To ; Chok, Kenneth S. H. ; Chan, Albert C. Y. ; Dai, Wing Chiu ; Chan, See Ching ; Poon, Ronnie T. P. ; Lo, Chung Mau</creatorcontrib><description><![CDATA[Background
The extent of hepatectomy for solitary hepatocellular carcinoma (HCC) <5 cm is controversial.
Methods
This is a retrospective review of patients with solitary HCC <5 cm, who underwent liver resection in a tertiary referral centre in Hong Kong between January 1989 and December 2009. Baseline demographics, liver function, peri-operative outcomes, and overall survival were compared.
Results
A total of 348 cirrhotic patients with a solitary HCC <5 cm underwent either major hepatectomy (
n
= 93) or minor hepatectomy (
n
= 255). Child-Pugh status did not differ, 98.9 vs. 96.1 % (
p
= 0.319); all patients who underwent major and minor hepatectomy were classified as Child-Pugh status A. Patients who underwent major hepatectomy had a larger median tumor size (4.0 vs. 2.5 cm,
p
< 0.001) and they also had more advanced stage of disease (stage I/II/IIIa: 10.8/55.9/33.3 vs. 26.7/52.9/20.4 %,
p
= 0.002). Median operative time for major hepatectomy was significantly longer (415 vs. 248 min,
p
< 0.001) and entailed greater blood loss (0.9 vs. 0.5 l,
p
< 0.001). Despite larger tumor size and more advanced stage of disease in the major hepatectomy group, hospital mortality (5.4 vs. 2.0 %,
p
= 0.185), complication rates (30.1 vs. 23.1 %,
p
= 0.234), and transfusion rate (10.8 vs. 11.4 %,
p
= 0.862) were the same between the two groups. Overall survival was significantly better for those who underwent major hepatectomy, with a median survival of 147.5 vs. 92.1 months (
p
= 0.043), and they had a better 5- and 10-year disease-free survival rate (57.3 vs. 40.2, 38.1 vs. 18.9 %,
p
= 0.003). In subgroup analysis, the 10-year survival for patients with stage II HCC and tumor <5 cm was 68.6 vs. 36.6 % in those who received minor hepatectomy alone (
p
= 0.027).
Conclusions
Major hepatectomy provided better long-term survival benefit in patients with HCC <5 cm, particularly in those with stage II disease.]]></description><identifier>ISSN: 0364-2313</identifier><identifier>EISSN: 1432-2323</identifier><identifier>DOI: 10.1007/s00268-014-2601-4</identifier><identifier>PMID: 24831671</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Abdominal Surgery ; Adult ; Aged ; Aged, 80 and over ; Blood Loss, Surgical ; Blood Transfusion ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Cardiac Surgery ; Disease-Free Survival ; Female ; Follow-Up Studies ; Future Liver Remnant ; Future Liver Remnant Volume ; General Surgery ; Hepatectomy - adverse effects ; Hepatectomy - methods ; Hospital Mortality ; Humans ; Intrahepatic Recurrence ; Liver Neoplasms - mortality ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Major Hepatectomy ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Recurrence, Local - etiology ; Neoplasm Staging ; Operative Time ; Retrospective Studies ; Surgery ; Survival Rate ; Thoracic Surgery ; Tumor Burden ; Vascular Surgery ; Young Adult</subject><ispartof>World journal of surgery, 2014-09, Vol.38 (9), p.2386-2394</ispartof><rights>Société Internationale de Chirurgie 2014</rights><rights>2014 The Author(s) under exclusive licence to Société Internationale de Chirurgie</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5581-6cf4a135c7e8bb66520f29d92dbf7aa1b03ebff9677a816c75b202182e99f5bf3</citedby><cites>FETCH-LOGICAL-c5581-6cf4a135c7e8bb66520f29d92dbf7aa1b03ebff9677a816c75b202182e99f5bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00268-014-2601-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00268-014-2601-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,41464,42533,45550,45551,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24831671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, Tiffany Cho Lam</creatorcontrib><creatorcontrib>Cheung, Tan To</creatorcontrib><creatorcontrib>Chok, Kenneth S. H.</creatorcontrib><creatorcontrib>Chan, Albert C. Y.</creatorcontrib><creatorcontrib>Dai, Wing Chiu</creatorcontrib><creatorcontrib>Chan, See Ching</creatorcontrib><creatorcontrib>Poon, Ronnie T. P.</creatorcontrib><creatorcontrib>Lo, Chung Mau</creatorcontrib><title>Treatment Strategy to Improve Long-Term Survival for Hepatocellular Carcinoma Smaller than 5 cm: Major Hepatectomy vs Minor Hepatectomy</title><title>World journal of surgery</title><addtitle>World J Surg</addtitle><addtitle>World J Surg</addtitle><description><![CDATA[Background
The extent of hepatectomy for solitary hepatocellular carcinoma (HCC) <5 cm is controversial.
Methods
This is a retrospective review of patients with solitary HCC <5 cm, who underwent liver resection in a tertiary referral centre in Hong Kong between January 1989 and December 2009. Baseline demographics, liver function, peri-operative outcomes, and overall survival were compared.
Results
A total of 348 cirrhotic patients with a solitary HCC <5 cm underwent either major hepatectomy (
n
= 93) or minor hepatectomy (
n
= 255). Child-Pugh status did not differ, 98.9 vs. 96.1 % (
p
= 0.319); all patients who underwent major and minor hepatectomy were classified as Child-Pugh status A. Patients who underwent major hepatectomy had a larger median tumor size (4.0 vs. 2.5 cm,
p
< 0.001) and they also had more advanced stage of disease (stage I/II/IIIa: 10.8/55.9/33.3 vs. 26.7/52.9/20.4 %,
p
= 0.002). Median operative time for major hepatectomy was significantly longer (415 vs. 248 min,
p
< 0.001) and entailed greater blood loss (0.9 vs. 0.5 l,
p
< 0.001). Despite larger tumor size and more advanced stage of disease in the major hepatectomy group, hospital mortality (5.4 vs. 2.0 %,
p
= 0.185), complication rates (30.1 vs. 23.1 %,
p
= 0.234), and transfusion rate (10.8 vs. 11.4 %,
p
= 0.862) were the same between the two groups. Overall survival was significantly better for those who underwent major hepatectomy, with a median survival of 147.5 vs. 92.1 months (
p
= 0.043), and they had a better 5- and 10-year disease-free survival rate (57.3 vs. 40.2, 38.1 vs. 18.9 %,
p
= 0.003). In subgroup analysis, the 10-year survival for patients with stage II HCC and tumor <5 cm was 68.6 vs. 36.6 % in those who received minor hepatectomy alone (
p
= 0.027).
Conclusions
Major hepatectomy provided better long-term survival benefit in patients with HCC <5 cm, particularly in those with stage II disease.]]></description><subject>Abdominal Surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Blood Loss, Surgical</subject><subject>Blood Transfusion</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Cardiac Surgery</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Future Liver Remnant</subject><subject>Future Liver Remnant Volume</subject><subject>General Surgery</subject><subject>Hepatectomy - adverse effects</subject><subject>Hepatectomy - methods</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Intrahepatic Recurrence</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Major Hepatectomy</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - etiology</subject><subject>Neoplasm Staging</subject><subject>Operative Time</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Survival Rate</subject><subject>Thoracic Surgery</subject><subject>Tumor Burden</subject><subject>Vascular Surgery</subject><subject>Young Adult</subject><issn>0364-2313</issn><issn>1432-2323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc1uEzEURi1ERUPhAdggS2zYTPHP2B6zoxGlRalYJIil5Zlch4nG42DPBOUNeAyehSero2lRQUKsLF2f79O9Ogi9oOScEqLeJEKYrApCy4JJQovyEZrRkrOCccYfoxnhMv9wyk_R05S2hFAliXyCTllZcSoVnaEfqwh28NAPeDlEO8DmgIeAr_0uhj3gReg3xQqix8sx7tu97bALEV_Bzg6hga4bOxvx3Mam7YO3eOlt10HEw1fbY_HrZ-Pf4hu7vY9AMwR_wPuEbzL_x_AZOnG2S_D87j1Dny_fr-ZXxeLTh-v5u0XRCFHRQjautJSLRkFV11IKRhzTa83WtVPW0ppwqJ3TUilbUdkoUTPCaMVAaydqx8_Q66k3H_hthDQY36bjJbaHMCZDhWBcVrrUGX31F7oNY-zzdkeKCp0hlSk6UU0MKUVwZhdbb-PBUGKOmsykyWRN5qjJlDnz8q55rD2sfyfuvWRAT8D3toPD_xvNl4_Li0uisuKcZVM25Vi_gfhg7X9udAud-a_F</recordid><startdate>201409</startdate><enddate>201409</enddate><creator>Wong, Tiffany Cho Lam</creator><creator>Cheung, Tan To</creator><creator>Chok, Kenneth S. H.</creator><creator>Chan, Albert C. Y.</creator><creator>Dai, Wing Chiu</creator><creator>Chan, See Ching</creator><creator>Poon, Ronnie T. P.</creator><creator>Lo, Chung Mau</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201409</creationdate><title>Treatment Strategy to Improve Long-Term Survival for Hepatocellular Carcinoma Smaller than 5 cm: Major Hepatectomy vs Minor Hepatectomy</title><author>Wong, Tiffany Cho Lam ; Cheung, Tan To ; Chok, Kenneth S. H. ; Chan, Albert C. Y. ; Dai, Wing Chiu ; Chan, See Ching ; Poon, Ronnie T. P. ; Lo, Chung Mau</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5581-6cf4a135c7e8bb66520f29d92dbf7aa1b03ebff9677a816c75b202182e99f5bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Abdominal Surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Blood Loss, Surgical</topic><topic>Blood Transfusion</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Cardiac Surgery</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Future Liver Remnant</topic><topic>Future Liver Remnant Volume</topic><topic>General Surgery</topic><topic>Hepatectomy - adverse effects</topic><topic>Hepatectomy - methods</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Intrahepatic Recurrence</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Major Hepatectomy</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - etiology</topic><topic>Neoplasm Staging</topic><topic>Operative Time</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Survival Rate</topic><topic>Thoracic Surgery</topic><topic>Tumor Burden</topic><topic>Vascular Surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, Tiffany Cho Lam</creatorcontrib><creatorcontrib>Cheung, Tan To</creatorcontrib><creatorcontrib>Chok, Kenneth S. H.</creatorcontrib><creatorcontrib>Chan, Albert C. Y.</creatorcontrib><creatorcontrib>Dai, Wing Chiu</creatorcontrib><creatorcontrib>Chan, See Ching</creatorcontrib><creatorcontrib>Poon, Ronnie T. P.</creatorcontrib><creatorcontrib>Lo, Chung Mau</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, Tiffany Cho Lam</au><au>Cheung, Tan To</au><au>Chok, Kenneth S. H.</au><au>Chan, Albert C. Y.</au><au>Dai, Wing Chiu</au><au>Chan, See Ching</au><au>Poon, Ronnie T. P.</au><au>Lo, Chung Mau</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment Strategy to Improve Long-Term Survival for Hepatocellular Carcinoma Smaller than 5 cm: Major Hepatectomy vs Minor Hepatectomy</atitle><jtitle>World journal of surgery</jtitle><stitle>World J Surg</stitle><addtitle>World J Surg</addtitle><date>2014-09</date><risdate>2014</risdate><volume>38</volume><issue>9</issue><spage>2386</spage><epage>2394</epage><pages>2386-2394</pages><issn>0364-2313</issn><eissn>1432-2323</eissn><abstract><![CDATA[Background
The extent of hepatectomy for solitary hepatocellular carcinoma (HCC) <5 cm is controversial.
Methods
This is a retrospective review of patients with solitary HCC <5 cm, who underwent liver resection in a tertiary referral centre in Hong Kong between January 1989 and December 2009. Baseline demographics, liver function, peri-operative outcomes, and overall survival were compared.
Results
A total of 348 cirrhotic patients with a solitary HCC <5 cm underwent either major hepatectomy (
n
= 93) or minor hepatectomy (
n
= 255). Child-Pugh status did not differ, 98.9 vs. 96.1 % (
p
= 0.319); all patients who underwent major and minor hepatectomy were classified as Child-Pugh status A. Patients who underwent major hepatectomy had a larger median tumor size (4.0 vs. 2.5 cm,
p
< 0.001) and they also had more advanced stage of disease (stage I/II/IIIa: 10.8/55.9/33.3 vs. 26.7/52.9/20.4 %,
p
= 0.002). Median operative time for major hepatectomy was significantly longer (415 vs. 248 min,
p
< 0.001) and entailed greater blood loss (0.9 vs. 0.5 l,
p
< 0.001). Despite larger tumor size and more advanced stage of disease in the major hepatectomy group, hospital mortality (5.4 vs. 2.0 %,
p
= 0.185), complication rates (30.1 vs. 23.1 %,
p
= 0.234), and transfusion rate (10.8 vs. 11.4 %,
p
= 0.862) were the same between the two groups. Overall survival was significantly better for those who underwent major hepatectomy, with a median survival of 147.5 vs. 92.1 months (
p
= 0.043), and they had a better 5- and 10-year disease-free survival rate (57.3 vs. 40.2, 38.1 vs. 18.9 %,
p
= 0.003). In subgroup analysis, the 10-year survival for patients with stage II HCC and tumor <5 cm was 68.6 vs. 36.6 % in those who received minor hepatectomy alone (
p
= 0.027).
Conclusions
Major hepatectomy provided better long-term survival benefit in patients with HCC <5 cm, particularly in those with stage II disease.]]></abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24831671</pmid><doi>10.1007/s00268-014-2601-4</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-2313 |
| ispartof | World journal of surgery, 2014-09, Vol.38 (9), p.2386-2394 |
| issn | 0364-2313 1432-2323 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1552368949 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; SpringerLink Journals - AutoHoldings |
| subjects | Abdominal Surgery Adult Aged Aged, 80 and over Blood Loss, Surgical Blood Transfusion Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Cardiac Surgery Disease-Free Survival Female Follow-Up Studies Future Liver Remnant Future Liver Remnant Volume General Surgery Hepatectomy - adverse effects Hepatectomy - methods Hospital Mortality Humans Intrahepatic Recurrence Liver Neoplasms - mortality Liver Neoplasms - pathology Liver Neoplasms - surgery Major Hepatectomy Male Medicine Medicine & Public Health Middle Aged Neoplasm Recurrence, Local - etiology Neoplasm Staging Operative Time Retrospective Studies Surgery Survival Rate Thoracic Surgery Tumor Burden Vascular Surgery Young Adult |
| title | Treatment Strategy to Improve Long-Term Survival for Hepatocellular Carcinoma Smaller than 5 cm: Major Hepatectomy vs Minor Hepatectomy |
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