Integrin‐linked kinase regulates the rate of platelet activation and is essential for the formation of stable thrombi

Summary Background Integrin‐linked kinase (ILK) and its associated complex of proteins are involved in many cellular activation processes, including cell adhesion and integrin signaling. We have previously demonstrated that mice with induced platelet ILK deficiency show reduced platelet activation a...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2014-08, Vol.12 (8), p.1342-1352
Hauptverfasser:	Jones, C. I., Tucker, K. L., Sasikumar, P., Sage, T., Kaiser, W. J., Moore, C., Emerson, M., Gibbins, J. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals embolism Flow Cytometry integrin alpha‐IIb beta‐3 integrin‐linked kinase Mice Mice, Transgenic Platelet Activation Platelet Glycoprotein GPIIb-IIIa Complex - metabolism platelets Protein Serine-Threonine Kinases - metabolism Thrombosis - enzymology thrombus
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