Delta-like 1 and lateral inhibition during hair cell formation in the chicken inner ear: evidence against cis-inhibition

The formation of the salt-and-pepper mosaic of hair cells and supporting cells in the sensory epithelia of the inner ear is regulated by Notch signalling and lateral inhibition, but the dynamics of this process and precise mode of action of delta-like 1 (Dll1) in this context are unclear. Here, we t...

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Veröffentlicht in:	Development (Cambridge) 2012-10, Vol.139 (20), p.3764-3774
Hauptverfasser:	Chrysostomou, Elena, Gale, Jonathan E, Daudet, Nicolas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cell Proliferation Chick Embryo Doxycycline - pharmacology Ear, Inner - embryology Ear, Inner - metabolism Gene Expression Regulation, Developmental Genes, Reporter Hair Cells, Auditory, Inner - cytology Hair Cells, Auditory, Inner - metabolism Intracellular Signaling Peptides and Proteins - metabolism Membrane Proteins - metabolism Receptors, Notch - metabolism Signal Transduction
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