Lovastatin decreases the synthesis of inflammatory mediators during epileptogenesis in the hippocampus of rats submitted to pilocarpine-induced epilepsy

Abstract Statins may act on inflammatory responses, decreasing oxidative stress and also reducing brain inflammation in several brain disorders. Epileptogenesis is a process in which a healthy brain becomes abnormal and predisposed to generating spontaneous seizures. We previously reported that lova...

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Veröffentlicht in:	Epilepsy & behavior 2014-07, Vol.36, p.68-73
Hauptverfasser:	Gouveia, T.L.F, Scorza, F.A, Iha, H.A, Frangiotti, M.I.B, Perosa, S.R, Cavalheiro, E.A, Silva, J.A, Feliciano, R.S, de Almeida, A.C, Naffah-Mazzacoratti, M.G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticholesteremic Agents - pharmacology Anticholesteremic Agents - therapeutic use Cytokines Cytokines - genetics Cytokines - metabolism Disease Models, Animal Epilepsy - chemically induced Epilepsy - drug therapy Epilepsy - pathology Epileptogenesis Gene Expression Regulation - drug effects Hippocampus - drug effects Hippocampus - metabolism Lovastatin Lovastatin - pharmacology Lovastatin - therapeutic use Male Muscarinic Agonists - toxicity Neurology Pilocarpine Pilocarpine - toxicity Rats Rats, Wistar RNA, Messenger - metabolism Temporal lobe epilepsy
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