Early versus delayed initiation of highly active antiretroviral therapy for HIV-positive adults with newly diagnosed pulmonary tuberculosis (TB-HAART): a prospective, international, randomised, placebo-controlled trial

Summary Background WHO guidelines recommend early initiation of antiretroviral therapy (ART) irrespective of CD4 cell count for all patients with tuberculosis who also have HIV, but evidence supporting this approach is poor quality. We assessed the effect of timing of ART initiation on tuberculosis...

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Veröffentlicht in:	The Lancet infectious diseases 2014-07, Vol.14 (7), p.563-571
Hauptverfasser:	Mfinanga, Sayoki G, PhD, Kirenga, Bruce J, MMed, Chanda, Duncan M, Dr, Mutayoba, Beatrice, MPhil, Mthiyane, Thuli, MPH, Yimer, Getnet, PhD, Ezechi, Oliver, MPH, Connolly, Cathy, MPH, Kapotwe, Vincent, DipDM, Muwonge, Catherine, MSc, Massaga, Julius, PhD, Sinkala, Edford, MMed, Kohi, Wanze, MPH, Lyantumba, Lucinda, BA, Nyakoojo, Grace, BA, Luwaga, Henry, MA, Doulla, Basra, BSc, Mzyece, Judith, BSc, Kapata, Nathan, MBChB, Vahedi, Mahnaz, MBBS, Mwaba, Peter, FRCP, Egwaga, Saidi, MMed, Adatu, Francis, MSc, Pym, Alex, PhD, Joloba, Moses, Prof, Rustomjee, Roxana, MD, Zumla, Alimuddin, Prof, Onyebujoh, Philip, FRCP
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult AIDS Anti-HIV Agents - administration & dosage Antiretroviral agents Antiretroviral Therapy, Highly Active - methods Bacterial diseases Bacterial diseases of the respiratory system Biological and medical sciences CD4 Lymphocyte Count - methods Drug Administration Schedule Drug therapy Female HIV HIV Infections - drug therapy HIV Infections - immunology HIV Infections - microbiology HIV Seropositivity - drug therapy HIV Seropositivity - microbiology Human bacterial diseases Human immunodeficiency virus Human viral diseases Humans Infectious Disease Infectious diseases Male Medical sciences Mortality Mycobacterium Prospective Studies Tuberculosis Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - virology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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