Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia

Leukotriene B4 (LTB4) has been implicated in the pathogenesis of allergic diseases. BLT2, a low‐affinity LTB4 receptor, is activated by LTB4 and 12(S)‐hydroxyheptadeca‐5Z,8E,10E ‐trienoic acid (12‐HHT). Although the high‐affinity LTB4 receptor BLT1 has been shown to exert proinflammatory roles, the...

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Veröffentlicht in:	The FASEB journal 2013-08, Vol.27 (8), p.3306-3314
Hauptverfasser:	Matsunaga, Yuko, Fukuyama, Satoru, Okuno, Toshiaki, Sasaki, Fumiyuki, Matsunobu, Takehiko, Asai, Yukari, Matsumoto, Koichiro, Saeki, Kazuko, Oike, Masahiro, Sadamura, Yukari, Machida, Kentaro, Nakanishi, Yoichi, Kubo, Masato, Yokomizo, Takehiko, Inoue, Hiromasa
Format:	Artikel
Sprache:	eng
Schlagworte:	12(S)hydroxyheptadeca‐5Z, 8E, 10E‐trienoic acid Adult Aged Animals asthma Asthma - genetics Asthma - immunology Asthma - metabolism Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Calcium - immunology Calcium - metabolism CD4+ T cell CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CHO Cells Cricetinae Cricetulus Cytokines - immunology Cytokines - metabolism Eosinophilia - genetics Eosinophilia - immunology Eosinophilia - metabolism Fatty Acids, Unsaturated - immunology Fatty Acids, Unsaturated - metabolism Humans interleukin‐13 Leukotriene B4 - immunology Leukotriene B4 - metabolism Lung - immunology Lung - metabolism Lung - pathology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Middle Aged Receptors, Leukotriene B4 - deficiency Receptors, Leukotriene B4 - genetics Receptors, Leukotriene B4 - immunology Reverse Transcriptase Polymerase Chain Reaction RNA Interference Young Adult
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