Novel self-nanoemulsifying formulation of quercetin: Implications of pro-oxidant activity on the anticancer efficacy

Abstract The present work focuses on the anticancer potential of quercetin (QT) loaded self-nanoemulsifying drug delivery system (QT-SNEDDS) composed of Capmul MCM, Tween 20 and ethanol. In vitro cell culture studies revealed potential cell cytotoxicity of developed formulation mediated by its abili...

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Veröffentlicht in:	Nanomedicine 2014-07, Vol.10 (5), p.e959-e969
Hauptverfasser:	Jain, Amit K., MPharm, Thanki, Kaushik, MPharm, Jain, Sanyog, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer efficacy Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects DNA Damage - drug effects Drug Delivery Systems - methods Female Humans Interleukin-6 - metabolism Internal Medicine Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism MCF-7 Cells Polysorbates - chemistry Prooxidant activity Prophylactic Quercetin Quercetin - chemistry Quercetin - pharmacology Reactive Oxygen Species - metabolism SNEDDS Tumor Necrosis Factor-alpha - metabolism
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