A Laminated Polymer Film Formulation for Enteric Delivery of Live Vaccine and Probiotic Bacteria

Live bacterial cells (LBCs) are administered orally as attenuated vaccines to deliver biopharmaceutical agents and as probiotics to improve gastrointestinal (GI) health. However, LBCs present unique formulation challenges and must survive GI antimicrobial defenses including gastric acid after admini...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 2014-07, Vol.103 (7), p.2022-2032
Hauptverfasser:	de Barros, João M.S., Scherer, Timothy, Charalampopoulos, Dimitrios, Khutoryanskiy, Vitaliy V., Edwards, Alexander D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins - chemistry Administration, Oral Bacteria Bacterial Vaccines - administration & dosage Bacterial Vaccines - microbiology Bifidobacterium - growth & development Cellulose - analogs & derivatives Cellulose - chemistry CFU, colony forming unit dissolution Drug Carriers - chemistry Drug Liberation Drug Stability drying EC, ethylcellulose enteric delivery Gastric Juice - chemistry Hydrogen-Ion Concentration LBCs, live bacterial cells MLF, multilayer laminated film Models, Biological Molecular Weight oral drug delivery PFL, polymer film laminate polymer film polymers probiotics Probiotics - administration & dosage SGF, simulated gastric fluid SIF, simulated intestinal fluid TF, thick film TPY, tryptone–phytone—yeast vaccine delivery Vaccines, Attenuated - administration & dosage
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!