Breaking good: the inexorable rise of BTK inhibitors in the treatment of chronic lymphocytic leukaemia

Summary Although expressed in several haematological lineages and involved in multiple different signalling pathways, Bruton tyrosine kinase (BTK) plays an indispensible role in B cells in signalling from the B cell receptor (BCR) for antigen. Many B cell malignancies remain dependent on constitutiv...

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Veröffentlicht in:	British journal of haematology 2014-07, Vol.166 (1), p.12-22
Hauptverfasser:	Hutchinson, Claire V., Dyer, Martin J. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use B cell receptor signalling Biological and medical sciences Bruton tyrosine kinase chronic lymphocytic leukaemia Clinical Trials as Topic - methods Hematologic and hematopoietic diseases Humans ibrutinib Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - enzymology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Molecular Targeted Therapy - methods Protein Kinase Inhibitors - therapeutic use Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - physiology Structure-Activity Relationship Tumors
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