Prion protein oligomer and its neurotoxicity

The prion diseases, also known as transmissible spongiform encephalopathies, are fatal neurodegenerative disorders. According to the 'protein only' hypothesis, the key molecular event in the pathogenesis of priori disease is the conformational conversion of the host-derived cellular prion protein (P...

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Veröffentlicht in:Acta biochimica et biophysica Sinica 2013-06, Vol.45 (6), p.442-451
Hauptverfasser: Huang, Pei, Lian, Fulin, Wen, Yi, Guo, Chenyun, Lin, Donghai
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Sprache:eng
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