Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly

IL-12p40 partners with the p35 and p19 polypeptides to generate the heterodimeric cytokines IL-12 and IL-23, respectively. These cytokines play critical and distinct roles in host defense. The assembly of these heterodimers is thought to take place within the cell, resulting in the secretion of full...

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Veröffentlicht in:	The Journal of immunology (1950) 2014-06, Vol.192 (12), p.6028-6036
Hauptverfasser:	Abdi, Kaveh, Singh, Nevil J, Spooner, Eric, Kessler, Benedikt M, Radaev, Sergei, Lantz, Larry, Xiao, Tsan Sam, Matzinger, Polly, Sun, Peter D, Ploegh, Hidde L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - immunology CD5 Antigens - genetics CD5 Antigens - immunology Dimerization Interleukin-12 - genetics Interleukin-12 - immunology Mice Mice, Knockout Proteomics Receptors, Immunologic - genetics Receptors, Immunologic - immunology Receptors, Scavenger
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