Hyperhomocysteinemia induces cardiac injury by up-regulation of p53-dependent Noxa and Bax expression through the p53 DNA methylation in ApoE-/- mice

Hyperhomocysteinemia （HHcy） is a risk factor for cardiovas- cular disease and has a strong correlation with heart failure. However, the effects of HHcy on cardiac tissue remain less well understood. To elucidate the role of p53-dependent apoptosis in HHcy-induced cardiac injury, we fed ApoE-/- mice...

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Veröffentlicht in:	Acta biochimica et biophysica Sinica 2013-05, Vol.45 (5), p.391-400
Hauptverfasser:	Ma, Shengchao, Zhang, Huiping, Sun, Weiwei, Gong, Huihui, Wang, Yanhua, Ma, Changjian, Wang, Ju, Cao, Chengjian, Yang, Xiaoling, Tian, Jue, Jiang, Yideng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins E - deficiency Bax蛋白 bcl-2-Associated X Protein - biosynthesis Cardiomyopathies - etiology Cardiomyopathies - physiopathology Caspase 3 - metabolism Caspase 9 - metabolism DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - biosynthesis DNA Methylation DNA甲基化 Hyperhomocysteinemia - physiopathology Male Mice p53基因 Proto-Oncogene Proteins c-bcl-2 - biosynthesis S-腺苷甲硫氨酸 Tumor Suppressor Protein p53 - genetics Up-Regulation 小鼠心肌损伤诱发高同型半胱氨酸血症
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