The inhibitory effect of IFN-γ on protease HTRA1 expression in rheumatoid arthritis

The high temperature requirement A1 (HTRA1) is a potent protease involved in many diseases, including rheumatoid arthritis (RA). However, the regulatory mechanisms that control HTRA1 expression need to be determined. In this study, we demonstrated that IFN-γ significantly inhibited the basal and LPS...

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Veröffentlicht in:	The Journal of immunology (1950) 2014-07, Vol.193 (1), p.130-138
Hauptverfasser:	Hou, Yuzhu, Lin, Haijiang, Zhu, Linnan, Liu, Zhaoting, Hu, Fanlei, Shi, Jianfeng, Yang, Tao, Shi, Xiaoyun, Guo, Huifang, Tan, Xiaotian, Zhang, Lianfeng, Wang, Qiang, Li, Zhanguo, Zhao, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Rheumatoid - chemically induced Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - metabolism Cell Line Collagen - toxicity Disease Models, Animal Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - genetics Gene Expression Regulation, Enzymologic - immunology High-Temperature Requirement A Serine Peptidase 1 Humans Interferon-gamma - genetics Interferon-gamma - immunology Interferon-gamma - metabolism Joints - immunology Joints - metabolism Joints - pathology Lipopolysaccharides - toxicity Mice Mice, Knockout p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - immunology p38 Mitogen-Activated Protein Kinases - metabolism Promoter Regions, Genetic - immunology Serine Endopeptidases - biosynthesis Serine Endopeptidases - genetics Serine Endopeptidases - immunology STAT1 Transcription Factor - genetics STAT1 Transcription Factor - immunology STAT1 Transcription Factor - metabolism
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