Bovine gamma delta T Cells Are a Major Regulatory T Cell Subset
In humans and mice, gamma delta T cells represent
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| Veröffentlicht in: | The Journal of immunology (1950) 2014-07, Vol.193 (1), p.208-222 |
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| container_end_page | 222 |
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| container_issue | 1 |
| container_start_page | 208 |
| container_title | The Journal of immunology (1950) |
| container_volume | 193 |
| creator | Guzman, Efrain Hope, Jayne Taylor, Geraldine Smith, Adrian L Cubillos-Zapata, Carolina Charleston, Bryan |
| description | In humans and mice, gamma delta T cells represent |
| doi_str_mv | 10.4049/jimmunol.1303398 |
| format | Article |
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In contrast, the gamma delta T cell compartment in ruminants accounts for 15-60% of the total circulating mononuclear lymphocytes. Despite the existence of CD4+CD25high Foxp3+ T cells in the bovine system, these are neither anergic nor suppressive. We present evidence showing that bovine gamma delta T cells are the major regulatory T cell subset in peripheral blood. These gamma delta T cells spontaneously secrete IL-10 and proliferate in response to IL-10, TGF- beta , and contact with APCs. IL-10-expressing gamma delta T cells inhibit Ag-specific and nonspecific proliferation of CD4+ and CD8+ T cells in vitro. APC subsets expressing IL-10 and TFG- beta regulate proliferation of gamma delta T cells producing IL-10. 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In contrast, the gamma delta T cell compartment in ruminants accounts for 15-60% of the total circulating mononuclear lymphocytes. Despite the existence of CD4+CD25high Foxp3+ T cells in the bovine system, these are neither anergic nor suppressive. We present evidence showing that bovine gamma delta T cells are the major regulatory T cell subset in peripheral blood. These gamma delta T cells spontaneously secrete IL-10 and proliferate in response to IL-10, TGF- beta , and contact with APCs. IL-10-expressing gamma delta T cells inhibit Ag-specific and nonspecific proliferation of CD4+ and CD8+ T cells in vitro. APC subsets expressing IL-10 and TFG- beta regulate proliferation of gamma delta T cells producing IL-10. 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| identifier | ISSN: 0022-1767 |
| ispartof | The Journal of immunology (1950), 2014-07, Vol.193 (1), p.208-222 |
| issn | 0022-1767 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Ruminantia |
| title | Bovine gamma delta T Cells Are a Major Regulatory T Cell Subset |
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