Respiratory syncytial virus: co-infection and paediatric lower respiratory tract infections
Comprehensive population-based data on the role of respiratory viruses in the development of lower respiratory tract infections (LRTIs) remain unclear. We investigated the incidence and effect of single and multiple infections with respiratory viruses on the risk of LRTIs in Vietnam. Population-base...
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| Veröffentlicht in: | The European respiratory journal 2013-08, Vol.42 (2), p.461-469 |
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| creator | YOSHIDA, Lay-Myint SUZUKI, Motoi MORIUCHI, Hiroyuki DUC ANH DANG ARIYOSHI, Koya HIEN ANH NGUYEN MINH NHAT LE THIEM DINH VU YOSHINO, Hiroshi SCHMIDT, Wolf-Peter THI THUY AI NGUYEN HUU THO LE MORIMOTO, Konosuke |
| description | Comprehensive population-based data on the role of respiratory viruses in the development of lower respiratory tract infections (LRTIs) remain unclear. We investigated the incidence and effect of single and multiple infections with respiratory viruses on the risk of LRTIs in Vietnam. Population-based prospective surveillance and a case-control study of hospitalised paediatric patients with acute respiratory infection (ARI) were conducted from April 2007 through to March 2010. Healthy controls were randomly recruited from the same community. Nasopharyngeal samples were collected and tested for 13 respiratory viruses using multiplex PCRs. 1992 hospitalised ARI episodes, including 397 (19.9%) with LRTIs, were enrolled. Incidence of hospitalised LRTIs among children aged |
| doi_str_mv | 10.1183/09031936.00101812 |
| format | Article |
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We investigated the incidence and effect of single and multiple infections with respiratory viruses on the risk of LRTIs in Vietnam. Population-based prospective surveillance and a case-control study of hospitalised paediatric patients with acute respiratory infection (ARI) were conducted from April 2007 through to March 2010. Healthy controls were randomly recruited from the same community. Nasopharyngeal samples were collected and tested for 13 respiratory viruses using multiplex PCRs. 1992 hospitalised ARI episodes, including 397 (19.9%) with LRTIs, were enrolled. Incidence of hospitalised LRTIs among children aged <24 months was 2171.9 per 100 000 (95% CI 1947.9-2419.7). The majority of ARI cases (60.9%) were positive for at least one virus. Human rhinovirus (24.2%), respiratory syncytial virus (20.1%) and influenza A virus (12.0%) were the most common and 9.5% had multiple-viral infections. Respiratory syncytial virus and human metapneumovirus infections independently increased the risk of LRTIs. Respiratory syncytial virus further increased the risk, when co-infected with human rhinovirus, human metapneumovirus and parainfluenza virus-3 but not with influenza A virus. The case-control analysis revealed that respiratory syncytial virus and influenza A virus increased the risk of ARI hospitalisation but not human rhinovirus. Respiratory syncytial virus is the leading pathogen associated with risk of ARI hospitalisation and LRTIs in Vietnam.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/09031936.00101812</identifier><identifier>PMID: 23645407</identifier><language>eng</language><publisher>Leeds: Maney</publisher><subject>Algorithms ; Biological and medical sciences ; Case-Control Studies ; Child, Preschool ; Coinfection ; Female ; Hospitalization ; Human metapneumovirus ; Human rhinovirus ; Human viral diseases ; Humans ; Incidence ; Infant ; Infectious diseases ; Influenza A virus ; Male ; Medical sciences ; Nasal Mucosa - metabolism ; Pneumology ; Polymerase Chain Reaction ; Population Surveillance ; Prospective Studies ; Respiratory syncytial virus ; Respiratory Syncytial Virus Infections - diagnosis ; Respiratory Syncytial Virus Infections - epidemiology ; Respiratory Syncytial Virus Infections - virology ; Respiratory Syncytial Viruses ; Respiratory system : syndromes and miscellaneous diseases ; Respiratory Tract Infections - diagnosis ; Respiratory Tract Infections - epidemiology ; Respiratory Tract Infections - virology ; Vietnam - epidemiology ; Viral diseases ; Viral diseases of the respiratory system and ent viral diseases</subject><ispartof>The European respiratory journal, 2013-08, Vol.42 (2), p.461-469</ispartof><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-f052a21f10e8d4edbeddddf0f0fc2c26e5bac9a4a23ef0c7764405014a7d114b3</citedby><cites>FETCH-LOGICAL-c364t-f052a21f10e8d4edbeddddf0f0fc2c26e5bac9a4a23ef0c7764405014a7d114b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27571732$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23645407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YOSHIDA, Lay-Myint</creatorcontrib><creatorcontrib>SUZUKI, Motoi</creatorcontrib><creatorcontrib>MORIUCHI, Hiroyuki</creatorcontrib><creatorcontrib>DUC ANH DANG</creatorcontrib><creatorcontrib>ARIYOSHI, Koya</creatorcontrib><creatorcontrib>HIEN ANH NGUYEN</creatorcontrib><creatorcontrib>MINH NHAT LE</creatorcontrib><creatorcontrib>THIEM DINH VU</creatorcontrib><creatorcontrib>YOSHINO, Hiroshi</creatorcontrib><creatorcontrib>SCHMIDT, Wolf-Peter</creatorcontrib><creatorcontrib>THI THUY AI NGUYEN</creatorcontrib><creatorcontrib>HUU THO LE</creatorcontrib><creatorcontrib>MORIMOTO, Konosuke</creatorcontrib><title>Respiratory syncytial virus: co-infection and paediatric lower respiratory tract infections</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>Comprehensive population-based data on the role of respiratory viruses in the development of lower respiratory tract infections (LRTIs) remain unclear. We investigated the incidence and effect of single and multiple infections with respiratory viruses on the risk of LRTIs in Vietnam. Population-based prospective surveillance and a case-control study of hospitalised paediatric patients with acute respiratory infection (ARI) were conducted from April 2007 through to March 2010. Healthy controls were randomly recruited from the same community. Nasopharyngeal samples were collected and tested for 13 respiratory viruses using multiplex PCRs. 1992 hospitalised ARI episodes, including 397 (19.9%) with LRTIs, were enrolled. Incidence of hospitalised LRTIs among children aged <24 months was 2171.9 per 100 000 (95% CI 1947.9-2419.7). The majority of ARI cases (60.9%) were positive for at least one virus. Human rhinovirus (24.2%), respiratory syncytial virus (20.1%) and influenza A virus (12.0%) were the most common and 9.5% had multiple-viral infections. Respiratory syncytial virus and human metapneumovirus infections independently increased the risk of LRTIs. Respiratory syncytial virus further increased the risk, when co-infected with human rhinovirus, human metapneumovirus and parainfluenza virus-3 but not with influenza A virus. The case-control analysis revealed that respiratory syncytial virus and influenza A virus increased the risk of ARI hospitalisation but not human rhinovirus. Respiratory syncytial virus is the leading pathogen associated with risk of ARI hospitalisation and LRTIs in Vietnam.</description><subject>Algorithms</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Child, Preschool</subject><subject>Coinfection</subject><subject>Female</subject><subject>Hospitalization</subject><subject>Human metapneumovirus</subject><subject>Human rhinovirus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Influenza A virus</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nasal Mucosa - metabolism</subject><subject>Pneumology</subject><subject>Polymerase Chain Reaction</subject><subject>Population Surveillance</subject><subject>Prospective Studies</subject><subject>Respiratory syncytial virus</subject><subject>Respiratory Syncytial Virus Infections - diagnosis</subject><subject>Respiratory Syncytial Virus Infections - epidemiology</subject><subject>Respiratory Syncytial Virus Infections - virology</subject><subject>Respiratory Syncytial Viruses</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Respiratory Tract Infections - diagnosis</subject><subject>Respiratory Tract Infections - epidemiology</subject><subject>Respiratory Tract Infections - virology</subject><subject>Vietnam - epidemiology</subject><subject>Viral diseases</subject><subject>Viral diseases of the respiratory system and ent viral diseases</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo7rr6A7xIL4KXrpl8NK03WfyCBUH05KFM0xQi3bYmqdJ_b5f90JszhznM8wzDS8g50DlAyq9pRjlkPJlTChRSYAdkCjzLYk4pPyTT9T5eAxNy4v3HSCWCwzGZMJ4IKaiakvcX4zvrMLRuiPzQ6CFYrKMv63p_E-k2tk1ldLBtE2FTRh2a0mJwVkd1-21c5P7owaEO0V7wp-Sowtqbs-2ckbf7u9fFY7x8fnha3C5jPb4R4opKhgwqoCYthSkLU45V0bE10ywxskCdoUDGTUW1UokQVFIQqEoAUfAZudrc7Vz72Rsf8pX12tQ1NqbtfQ5SQsJTKeT_qAAlWaZkNqKwQbVrvXemyjtnV-iGHGi-jj_fxZ_v4h-di-35vliZcm_s8h6Byy2AXmNdOWy09b-ckgoUZ_wH3imOMQ</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>YOSHIDA, Lay-Myint</creator><creator>SUZUKI, Motoi</creator><creator>MORIUCHI, Hiroyuki</creator><creator>DUC ANH DANG</creator><creator>ARIYOSHI, Koya</creator><creator>HIEN ANH NGUYEN</creator><creator>MINH NHAT LE</creator><creator>THIEM DINH VU</creator><creator>YOSHINO, Hiroshi</creator><creator>SCHMIDT, Wolf-Peter</creator><creator>THI THUY AI NGUYEN</creator><creator>HUU THO LE</creator><creator>MORIMOTO, Konosuke</creator><general>Maney</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20130801</creationdate><title>Respiratory syncytial virus: co-infection and paediatric lower respiratory tract infections</title><author>YOSHIDA, Lay-Myint ; SUZUKI, Motoi ; MORIUCHI, Hiroyuki ; DUC ANH DANG ; ARIYOSHI, Koya ; HIEN ANH NGUYEN ; MINH NHAT LE ; THIEM DINH VU ; YOSHINO, Hiroshi ; SCHMIDT, Wolf-Peter ; THI THUY AI NGUYEN ; HUU THO LE ; MORIMOTO, Konosuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-f052a21f10e8d4edbeddddf0f0fc2c26e5bac9a4a23ef0c7764405014a7d114b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Algorithms</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Child, Preschool</topic><topic>Coinfection</topic><topic>Female</topic><topic>Hospitalization</topic><topic>Human metapneumovirus</topic><topic>Human rhinovirus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Influenza A virus</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nasal Mucosa - metabolism</topic><topic>Pneumology</topic><topic>Polymerase Chain Reaction</topic><topic>Population Surveillance</topic><topic>Prospective Studies</topic><topic>Respiratory syncytial virus</topic><topic>Respiratory Syncytial Virus Infections - diagnosis</topic><topic>Respiratory Syncytial Virus Infections - epidemiology</topic><topic>Respiratory Syncytial Virus Infections - virology</topic><topic>Respiratory Syncytial Viruses</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Respiratory Tract Infections - diagnosis</topic><topic>Respiratory Tract Infections - epidemiology</topic><topic>Respiratory Tract Infections - virology</topic><topic>Vietnam - epidemiology</topic><topic>Viral diseases</topic><topic>Viral diseases of the respiratory system and ent viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YOSHIDA, Lay-Myint</creatorcontrib><creatorcontrib>SUZUKI, Motoi</creatorcontrib><creatorcontrib>MORIUCHI, Hiroyuki</creatorcontrib><creatorcontrib>DUC ANH DANG</creatorcontrib><creatorcontrib>ARIYOSHI, Koya</creatorcontrib><creatorcontrib>HIEN ANH NGUYEN</creatorcontrib><creatorcontrib>MINH NHAT LE</creatorcontrib><creatorcontrib>THIEM DINH VU</creatorcontrib><creatorcontrib>YOSHINO, Hiroshi</creatorcontrib><creatorcontrib>SCHMIDT, Wolf-Peter</creatorcontrib><creatorcontrib>THI THUY AI NGUYEN</creatorcontrib><creatorcontrib>HUU THO LE</creatorcontrib><creatorcontrib>MORIMOTO, Konosuke</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YOSHIDA, Lay-Myint</au><au>SUZUKI, Motoi</au><au>MORIUCHI, Hiroyuki</au><au>DUC ANH DANG</au><au>ARIYOSHI, Koya</au><au>HIEN ANH NGUYEN</au><au>MINH NHAT LE</au><au>THIEM DINH VU</au><au>YOSHINO, Hiroshi</au><au>SCHMIDT, Wolf-Peter</au><au>THI THUY AI NGUYEN</au><au>HUU THO LE</au><au>MORIMOTO, Konosuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Respiratory syncytial virus: co-infection and paediatric lower respiratory tract infections</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>2013-08-01</date><risdate>2013</risdate><volume>42</volume><issue>2</issue><spage>461</spage><epage>469</epage><pages>461-469</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>Comprehensive population-based data on the role of respiratory viruses in the development of lower respiratory tract infections (LRTIs) remain unclear. We investigated the incidence and effect of single and multiple infections with respiratory viruses on the risk of LRTIs in Vietnam. Population-based prospective surveillance and a case-control study of hospitalised paediatric patients with acute respiratory infection (ARI) were conducted from April 2007 through to March 2010. Healthy controls were randomly recruited from the same community. Nasopharyngeal samples were collected and tested for 13 respiratory viruses using multiplex PCRs. 1992 hospitalised ARI episodes, including 397 (19.9%) with LRTIs, were enrolled. Incidence of hospitalised LRTIs among children aged <24 months was 2171.9 per 100 000 (95% CI 1947.9-2419.7). The majority of ARI cases (60.9%) were positive for at least one virus. Human rhinovirus (24.2%), respiratory syncytial virus (20.1%) and influenza A virus (12.0%) were the most common and 9.5% had multiple-viral infections. Respiratory syncytial virus and human metapneumovirus infections independently increased the risk of LRTIs. Respiratory syncytial virus further increased the risk, when co-infected with human rhinovirus, human metapneumovirus and parainfluenza virus-3 but not with influenza A virus. The case-control analysis revealed that respiratory syncytial virus and influenza A virus increased the risk of ARI hospitalisation but not human rhinovirus. Respiratory syncytial virus is the leading pathogen associated with risk of ARI hospitalisation and LRTIs in Vietnam.</abstract><cop>Leeds</cop><pub>Maney</pub><pmid>23645407</pmid><doi>10.1183/09031936.00101812</doi><tpages>9</tpages></addata></record> |
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| ispartof | The European respiratory journal, 2013-08, Vol.42 (2), p.461-469 |
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| subjects | Algorithms Biological and medical sciences Case-Control Studies Child, Preschool Coinfection Female Hospitalization Human metapneumovirus Human rhinovirus Human viral diseases Humans Incidence Infant Infectious diseases Influenza A virus Male Medical sciences Nasal Mucosa - metabolism Pneumology Polymerase Chain Reaction Population Surveillance Prospective Studies Respiratory syncytial virus Respiratory Syncytial Virus Infections - diagnosis Respiratory Syncytial Virus Infections - epidemiology Respiratory Syncytial Virus Infections - virology Respiratory Syncytial Viruses Respiratory system : syndromes and miscellaneous diseases Respiratory Tract Infections - diagnosis Respiratory Tract Infections - epidemiology Respiratory Tract Infections - virology Vietnam - epidemiology Viral diseases Viral diseases of the respiratory system and ent viral diseases |
| title | Respiratory syncytial virus: co-infection and paediatric lower respiratory tract infections |
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