HLA-G5 induces IL-4 secretion critical for successful pregnancy through differential expression of ILT2 receptor on decidual CD4⁺ T cells and macrophages

Successful pregnancy in humans has been associated with production of IL-4 by T cells at the feto-maternal interface. Soluble HLA-G5 produced by trophoblasts potentially controls the decidual T cell cytokine profile. We studied the effect of HLA-G5 on the cytokine profile of purified human macrophag...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2013-10, Vol.191 (7), p.3651-3662
Hauptverfasser:	Lombardelli, Letizia, Aguerre-Girr, Maryse, Logiodice, Federica, Kullolli, Ornela, Casart, Ysabel, Polgar, Beata, Berrebi, Alain, Romagnani, Sergio, Maggi, Enrico, Le Bouteiller, Philippe, Piccinni, Marie-Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens - immunology Antigens, CD - genetics Antigens, CD - metabolism CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Epitopes, T-Lymphocyte - immunology Female Gene Expression Regulation HLA-G Antigens - immunology Humans Interleukin-12 - biosynthesis Interleukin-4 - secretion Leukocyte Immunoglobulin-like Receptor B1 Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Lymphocyte Activation - genetics Lymphocyte Activation - immunology Macrophage Activation - genetics Macrophage Activation - immunology Macrophages - immunology Macrophages - metabolism Models, Immunological Pregnancy Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Tetanus Toxin - immunology Trophoblasts - immunology Trophoblasts - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!