Immunophenotypical Characterization of Macrophages in Rat Bleomycin-Induced Scleroderma

Scleroderma is a skin disorder characterized by persistent fibrosis. Macrophage properties influencing cutaneous fibrogenesis remain to be fully elucidated. In this rat (F344 rats) model of scleroderma, at 1, 2, 3, and 4 weeks after initiation of daily subcutaneous injections of bleomycin (BLM; 100...

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Veröffentlicht in:	Veterinary pathology 2013-01, Vol.50 (1), p.76-85
Hauptverfasser:	Juniantito, V., Izawa, T., Yuasa, T., Ichikawa, C., Yano, R., Kuwamura, M., Yamate, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - toxicity Bleomycin - toxicity Disease Models, Animal Fibrosis - immunology Fibrosis - metabolism Galectin 3 - genetics Galectin 3 - metabolism Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - immunology Histocompatibility Antigens Class II - metabolism Humans Immunohistochemistry Immunophenotyping Macrophages - immunology Macrophages - metabolism Male Myofibroblasts - immunology Myofibroblasts - metabolism Rats Rats, Inbred F344 RNA, Messenger - metabolism Scleroderma, Localized - chemically induced Scleroderma, Localized - immunology Scleroderma, Localized - metabolism Skin - immunology Skin - pathology Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism
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