Receptor-interacting protein 2 gene silencing attenuates allergic airway inflammation

Persistent activation of NF-κB has been associated with the development of asthma. Receptor-interacting protein 2 (Rip2) is a transcriptional product of NF-κB activation. It is an adaptor protein with serine/threonine kinase activity and has been shown to positively regulate NF-κB activity. We inves...

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Veröffentlicht in:	The Journal of immunology (1950) 2013-09, Vol.191 (5), p.2691-2699
Hauptverfasser:	Goh, Fera Y, Cook, Katrina L T P, Upton, Nadine, Tao, Lin, Lah, Lin Chin, Leung, Bernard P, Wong, W S Fred
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Asthma - immunology Asthma - metabolism Disease Models, Animal Female Gene Silencing Hypersensitivity - immunology Hypersensitivity - metabolism Immunoblotting Mice Mice, Inbred BALB C NF-kappa B - immunology NF-kappa B - metabolism Pneumonia - immunology Pneumonia - metabolism Receptor-Interacting Protein Serine-Threonine Kinases - immunology Receptor-Interacting Protein Serine-Threonine Kinases - metabolism Respiratory Hypersensitivity - immunology Respiratory Hypersensitivity - metabolism RNA, Small Interfering
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