In vitro organogenesis in three dimensions: self-organising stem cells
Organ formation during embryogenesis is a complex process that involves various local cell-cell interactions at the molecular and mechanical levels. Despite this complexity, organogenesis can be modelled in vitro. In this article, we focus on two recent examples in which embryonic stem cells can sel...
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| Veröffentlicht in: | Development (Cambridge) 2012-11, Vol.139 (22), p.4111-4121 |
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| container_title | Development (Cambridge) |
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| creator | Sasai, Yoshiki Eiraku, Mototsugu Suga, Hidetaka |
| description | Organ formation during embryogenesis is a complex process that involves various local cell-cell interactions at the molecular and mechanical levels. Despite this complexity, organogenesis can be modelled in vitro. In this article, we focus on two recent examples in which embryonic stem cells can self-organise into three-dimensional structures - the optic cup and the pituitary epithelium; and one case of self-organising adult stem cells - the gut epithelium. We summarise how these approaches have revealed intrinsic programs that drive locally autonomous modes of organogenesis and homeostasis. We also attempt to interpret the results of previous in vivo studies of retinal development in light of the self-organising nature of the retina. |
| doi_str_mv | 10.1242/dev.079590 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Development (Cambridge), 2012-11, Vol.139 (22), p.4111-4121 |
| issn | 0950-1991 1477-9129 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Adult Stem Cells - cytology Animals Cell Differentiation Embryonic Stem Cells - cytology Epithelial Cells Eye - embryology Humans Intestinal Mucosa - cytology Intestinal Mucosa - embryology Organogenesis - physiology Pituitary Gland - embryology Retina - embryology |
| title | In vitro organogenesis in three dimensions: self-organising stem cells |
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