RG7212 Anti-TWEAK mAb Inhibits Tumor Growth through Inhibition of Tumor Cell Proliferation and Survival Signaling and by Enhancing the Host Antitumor Immune Response

To explore the role of TWEAK in tumor growth and antitumor immune response and the activity and mechanism of RG7212, an antagonistic anti-TWEAK antibody, in tumor models. TWEAK-induced signaling and gene expression were explored in tumor cell lines and inhibition of these effects and antitumor effic...

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Veröffentlicht in:	Clinical cancer research 2013-10, Vol.19 (20), p.5686-5698
Hauptverfasser:	XUEFENG YIN, LUISTRO, Leopoldo, XIAOQIAN WANG, PACKMAN, Kathryn, ROSINSKI, Jim, BERKOFSKY-FESSLER, Windy, TANG, Jian-Ping, PANT, Saumya, GEHO, David, VEGA-HARRING, Suzana, DEMARIO, Mark, LEVITSKY, Hy, HUA ZHONG, SIMCOX, Mary, SMITH, Melissa, NEVINS, Tom, SCHOSTACK, Kathleen, HILTON, Holly, LIN, Tai-An, TRUITT, Theresa, BIONDI, Denise
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cytokine TWEAK Disease Models, Animal Gene Expression Regulation, Neoplastic - drug effects Humans Medical sciences Mice Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasms - genetics Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology Pharmacology. Drug treatments Signal Transduction - drug effects Tumor Burden - drug effects Tumor Microenvironment - drug effects Tumor Microenvironment - genetics Tumor Microenvironment - immunology Tumor Necrosis Factors - antagonists & inhibitors Tumor Necrosis Factors - metabolism Tumors Xenograft Model Antitumor Assays
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