Cutting edge: Type I IFN drives emergency myelopoiesis and peripheral myeloid expansion during chronic TLR7 signaling

Mice overexpressing TLR7 (TLR7.1 mice) are a model of systemic lupus erythematosus pathogenesis and exhibit peripheral myeloid expansion. We show that TLR7.1 mice have a dramatic expansion of splenic cells that derive from granulocyte/macrophage progenitors (GMP) compared with wild-type mice. In the...

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Veröffentlicht in:	The Journal of immunology (1950) 2013-02, Vol.190 (3), p.886-891
Hauptverfasser:	Buechler, Matthew B, Teal, Thomas H, Elkon, Keith B, Hamerman, Jessica A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Ly - analysis Bone Marrow - pathology Cell Division Cell Lineage Dendritic Cells - immunology Disease Models, Animal Gene Expression Regulation - immunology Granulocytes - pathology Interferon Type I - biosynthesis Interferon Type I - genetics Interferon Type I - physiology Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology Macrophages - pathology Membrane Glycoproteins - agonists Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Membrane Glycoproteins - physiology Membrane Proteins - analysis Mice Mice, Transgenic Models, Immunological Myeloid Cells - pathology Myelopoiesis - physiology Radiation Chimera Receptor, Interferon alpha-beta - deficiency RNA, Messenger - biosynthesis RNA, Messenger - genetics Signal Transduction - physiology Spleen - pathology Toll-Like Receptor 7 - agonists Toll-Like Receptor 7 - biosynthesis Toll-Like Receptor 7 - genetics Toll-Like Receptor 7 - physiology
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