Control of the STAT6-BCL6 antagonism by SWAP-70 determines IgE production

Asthma and allergies are major health concerns in which Ig isotype E plays a pivotal role. Ag-bound IgE drives mast cells and basophils into exocytosis, thereby promoting allergic and potentially anaphylactic reactions. The importance of tightly regulated IgE production is underscored by severe immu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The Journal of immunology (1950) 2013-05, Vol.190 (10), p.4946-4955
Hauptverfasser: Audzevich, Tatsiana, Pearce, Glen, Breucha, Michael, Günal, Gamze, Jessberger, Rolf
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!