Retinoic acid attenuates rheumatoid inflammation in mice

Retinoic acid is the active vitamin A derivative and is well-known to have diverse immunomodulatory actions. In this study, we investigated the impact of all-trans retinoic acid (ATRA), a biologic key metabolite of vitamin A, on the development of arthritis and the pathophysiologic mechanisms by whi...

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Veröffentlicht in:	The Journal of immunology (1950) 2012-07, Vol.189 (2), p.1062-1071
Hauptverfasser:	Kwok, Seung-Ki, Park, Mi-Kyung, Cho, Mi-La, Oh, Hye-Jwa, Park, Eun-Mi, Lee, Dong-Gun, Lee, Jennifer, Kim, Ho-Youn, Park, Sung-Hwan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Cattle Collagen Type II - toxicity Disease Models, Animal Immunity, Humoral - drug effects Immunity, Humoral - immunology Inflammation - drug therapy Inflammation - immunology Inflammation - pathology Inflammation Mediators - administration & dosage Inflammation Mediators - therapeutic use Male Mice Mice, Inbred DBA Osteoclasts - drug effects Osteoclasts - immunology Osteoclasts - pathology Th17 Cells - drug effects Th17 Cells - immunology Th17 Cells - pathology Tretinoin - administration & dosage Tretinoin - therapeutic use
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