Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus

Objectives Recent data debate the suitability of Helios, an Ikaros family member, as a marker for thymic-derived regulatory T cells (Treg). Nevertheless, Foxp3+ Helios+ Treg may be of particular relevance in mediating immune tolerance in chronic autoimmunity, such as systemic lupus erythematosus (SL...

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Veröffentlicht in:	Annals of the rheumatic diseases 2013-09, Vol.72 (9), p.1549-1558
Hauptverfasser:	Alexander, Tobias, Sattler, Arne, Templin, Lars, Kohler, Siegfried, Groß, Christian, Meisel, Andreas, Sawitzki, Birgit, Burmester, Gerd-Rüdiger, Arnold, Renate, Radbruch, Andreas, Thiel, Andreas, Hiepe, Falk
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Antigens Arthritis Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Autoimmune Diseases Autoimmunity Biomarkers - metabolism Cytokines Disease DNA Methylation Female Flow Cytometry Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene Silencing Genotype & phenotype Humans Ikaros Transcription Factor - metabolism Immunophenotyping Lupus Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology Lymphocytes Male Middle Aged Scleroderma, Systemic - immunology Scleroderma, Systemic - pathology Studies Systemic Lupus Erythematosus T cell receptors T Cells T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - pathology
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