Intravesical Delivery of Small Activating RNA Formulated into Lipid Nanoparticles Inhibits Orthotopic Bladder Tumor Growth

Practical methods for enhancing protein production in vivo remain a challenge. RNA activation (RNAa) is emerging as one potential solution by using double-stranded RNA (dsRNA) to increase endogenous gene expression. This approach, although related to RNA interference (RNAi), facilitates a response o...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2012-10, Vol.72 (19), p.5069-5079
Hauptverfasser:	MOO RIM KANG, YANG, Glen, PLACE, Robert F, CHARISSE, Klaus, EPSTEIN-BARASH, Hila, MANOHARAN, Muthiah, LI, Long-Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravesical Antineoplastic agents Apoptosis - genetics Biological and medical sciences Caspase 3 - metabolism Cell Cycle Checkpoints - genetics Cell Line, Tumor Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Drug Delivery Systems - methods Gene Expression Regulation, Neoplastic Humans Immunoblotting Immunohistochemistry Kaplan-Meier Estimate Ki-67 Antigen - metabolism Lipids - chemistry Medical sciences Nanoparticles - administration & dosage Nanoparticles - chemistry Nephrology. Urinary tract diseases Pharmacology. Drug treatments Reverse Transcriptase Polymerase Chain Reaction RNA, Double-Stranded - chemistry RNA, Double-Stranded - genetics Tumor Burden - genetics Tumors Tumors of the urinary system Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - therapy Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland Xenograft Model Antitumor Assays - methods
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