Dynamics of human prothymocytes and xenogeneic thymopoiesis in hematopoietic stem cell-engrafted nonobese diabetic-SCID/IL-2rγnull mice

To model the developmental pattern of human prothymocytes and thymopoiesis, we used NOD-scid/γc(-/-) mice grafted with human umbilical cord blood CD34(+) hematopoietic progenitor cells (HPCs). Human prothymocytes developed in the murine bone marrow (BM) from multipotent CD34(++)CD38(lo)lineage(-) HP...

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Veröffentlicht in:	The Journal of immunology (1950) 2012-08, Vol.189 (4), p.1648-1660
Hauptverfasser:	Parietti, Véronique, Nelson, Elisabeth, Telliam, Gladys, Le Noir, Sandrine, Pla, Marika, Delord, Marc, Vanneaux, Valérie, Mohtashami, Mahmood, Macintyre, Elizabeth A, Gluckman, Jean Claude, Asnafi, Vahid, Zúñiga-Pflücker, Juan-Carlos, Larghero, Jérôme, Canque, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - cytology Cell Differentiation - immunology Cell Lineage - immunology Hematopoietic Stem Cell Transplantation Humans Lymphoid Progenitor Cells - cytology Lymphopoiesis - physiology Mice Mice, Inbred NOD Mice, SCID Oligonucleotide Array Sequence Analysis Reverse Transcriptase Polymerase Chain Reaction T-Lymphocytes - cytology Thymus Gland - cytology Transplantation, Heterologous
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