Prostate Cancer Progression Correlates with Increased Humoral Immune Response to a Human Endogenous Retrovirus GAG Protein

Human endogenous retroviruses (HERV) encode 8% of the human genome. While HERVs may play a role in autoimmune and neoplastic disease, no mechanistic association has yet been established. We studied the expression and immunogenicity of a HERV-K GAG protein encoded on chromosome 22q11.23 in relation t...

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Veröffentlicht in:	Clinical cancer research 2013-11, Vol.19 (22), p.6112-6125
Hauptverfasser:	REIS, Bernardo Sgarbi, JUNGBLUTH, Achim A, SCARDINO, Peter T, SLOVIN, Susan, SUBUDHI, Sumit K, REUTER, Victor E, SAVAGE, Caroline, ALLISON, James P, MELAMED, Jonathan, JÄGER, Elke, RITTER, Gerd, OLD, Lloyd J, FROSINA, Denise, GNJATIC, Sacha, HOLZ, Megan, RITTER, Erika, NAKAYAMA, Eiichi, ISHIDA, Toshiaki, OBATA, Yuichi, CARVER, Brett, SCHER, Howard
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antibodies - blood Antibodies - immunology Antineoplastic agents Autoantibodies - immunology Biological and medical sciences Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Biomarkers, Tumor - immunology Cell Line, Tumor Chromosomes, Human, Pair 22 - virology Disease Progression DNA Methylation Endogenous Retroviruses - immunology Gene Products, gag - biosynthesis Gene Products, gag - genetics Gene Products, gag - immunology Gynecology. Andrology. Obstetrics HeLa Cells Human endogenous retrovirus Humans Male Male genital diseases Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Nephrology. Urinary tract diseases Pharmacology. Drug treatments Promoter Regions, Genetic Prostatic Neoplasms - genetics Prostatic Neoplasms - immunology Prostatic Neoplasms - mortality Survival Tumors Tumors of the urinary system Urinary tract. Prostate gland
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