Changes in Histone Modification and DNA Methylation of the StAR and Cyp19a1 Promoter Regions in Granulosa Cells Undergoing Luteinization during Ovulation In Rats

The ovulatory LH surge induces rapid up-regulation of steroidogenic acute regulatory (StAR) protein and rapid down-regulation of aromatase (Cyp19a1) in granulosa cells (GCs) undergoing luteinization during ovulation. This study investigated in vivo whether epigenetic mechanisms including histone mod...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2013-01, Vol.154 (1), p.458-470
Hauptverfasser:	Lee, Lifa, Asada, Hiromi, Kizuka, Fumie, Tamura, Isao, Maekawa, Ryo, Taketani, Toshiaki, Sato, Shun, Yamagata, Yoshiaki, Tamura, Hiroshi, Sugino, Norihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Aromatase Aromatase - genetics Biological and medical sciences Chorionic gonadotropin Chorionic Gonadotropin - pharmacology Chromatin Deoxyribonuclease Deoxyribonuclease I DNA methylation DNA Methylation - drug effects DNA Methylation - genetics Epigenetics Female Fundamental and applied biological sciences. Psychology Gene expression Gonadotropins Granulosa cells Granulosa Cells - drug effects Granulosa Cells - metabolism Histones Histones - drug effects Histones - metabolism Horses Immunoprecipitation In vivo methods and tests Injection Luteinization - drug effects Luteinization - genetics Lysine Ovulation Ovulation - drug effects Ovulation - genetics Phosphoproteins - genetics Pituitary (anterior) Promoter Regions, Genetic - drug effects Promoter Regions, Genetic - genetics Proteins Rats Vertebrates: endocrinology
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