Emerging Roles for Lysophospholipid Mediators in Pregnancy
Recent progress in lipid research has unveiled new biologic roles for lysophospholipids as mediators of intercellular signaling. Lysophosphatidic acid (LPA) and sphingosine 1‐phosphate (S1P) are representative lysophospholipids. Accumulating evidence suggests that, acting as intercellular mediators,...
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| Veröffentlicht in: | American journal of reproductive immunology (1989) 2014-08, Vol.72 (2), p.182-191 |
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| container_title | American journal of reproductive immunology (1989) |
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| creator | Nagamatsu, Takeshi Iwasawa-Kawai, Yuki Ichikawa, Mayuko Kawana, Kei Yamashita, Takahiro Osuga, Yutaka Fujii, Tomoyuki Schust, Danny J. |
| description | Recent progress in lipid research has unveiled new biologic roles for lysophospholipids as mediators of intercellular signaling. Lysophosphatidic acid (LPA) and sphingosine 1‐phosphate (S1P) are representative lysophospholipids. Accumulating evidence suggests that, acting as intercellular mediators, these and other lysophospholipids may play important roles in physiological and pathological situations. This review discusses the possible involvement of LPA and S1P in reproductive processes, with a focus on the regulatory mechanisms of pregnancy maintenance. As LPA promotes prostaglandin synthesis, mediators in the LPA pathway may also play a significant role in implantation and parturition. S1P signaling is thought to be essential in vascular formation within the uteroplacental unit and in fetomaternal immunologic interactions. Derangements in either one of these lysophospholipid signaling pathways could result in pregnancy complications that may include implantation failure, preeclampsia, and preterm labor. |
| doi_str_mv | 10.1111/aji.12239 |
| format | Article |
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Lysophosphatidic acid (LPA) and sphingosine 1‐phosphate (S1P) are representative lysophospholipids. Accumulating evidence suggests that, acting as intercellular mediators, these and other lysophospholipids may play important roles in physiological and pathological situations. This review discusses the possible involvement of LPA and S1P in reproductive processes, with a focus on the regulatory mechanisms of pregnancy maintenance. As LPA promotes prostaglandin synthesis, mediators in the LPA pathway may also play a significant role in implantation and parturition. S1P signaling is thought to be essential in vascular formation within the uteroplacental unit and in fetomaternal immunologic interactions. Derangements in either one of these lysophospholipid signaling pathways could result in pregnancy complications that may include implantation failure, preeclampsia, and preterm labor.</description><identifier>ISSN: 1046-7408</identifier><identifier>EISSN: 1600-0897</identifier><identifier>DOI: 10.1111/aji.12239</identifier><identifier>PMID: 24689547</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Endometrium - immunology ; Endometrium - metabolism ; Female ; Humans ; Lysophosphatidic acid ; lysophospholipid ; Lysophospholipids - immunology ; Lysophospholipids - metabolism ; Maternal-Fetal Exchange - immunology ; Medical research ; Neovascularization, Physiologic ; Obstetric Labor, Premature - immunology ; Obstetric Labor, Premature - metabolism ; Obstetric Labor, Premature - pathology ; Ovary - immunology ; Ovary - metabolism ; Parturition - immunology ; Placenta - blood supply ; Placenta - immunology ; Placenta - metabolism ; Pre-Eclampsia - immunology ; Pre-Eclampsia - metabolism ; Pre-Eclampsia - pathology ; Pregnancy ; Pregnancy - immunology ; Prostaglandins - biosynthesis ; Prostaglandins - immunology ; reproduction ; Signal Transduction ; Sphingosine - analogs & derivatives ; Sphingosine - immunology ; Sphingosine - metabolism ; sphingosine 1-phosphate</subject><ispartof>American journal of reproductive immunology (1989), 2014-08, Vol.72 (2), p.182-191</ispartof><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5609-a91d661728f273d6857e258f1e4ec4c26bb0222be953ab88028e25c75e724a5a3</citedby><cites>FETCH-LOGICAL-c5609-a91d661728f273d6857e258f1e4ec4c26bb0222be953ab88028e25c75e724a5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faji.12239$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faji.12239$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24689547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagamatsu, Takeshi</creatorcontrib><creatorcontrib>Iwasawa-Kawai, Yuki</creatorcontrib><creatorcontrib>Ichikawa, Mayuko</creatorcontrib><creatorcontrib>Kawana, Kei</creatorcontrib><creatorcontrib>Yamashita, Takahiro</creatorcontrib><creatorcontrib>Osuga, Yutaka</creatorcontrib><creatorcontrib>Fujii, Tomoyuki</creatorcontrib><creatorcontrib>Schust, Danny J.</creatorcontrib><title>Emerging Roles for Lysophospholipid Mediators in Pregnancy</title><title>American journal of reproductive immunology (1989)</title><addtitle>Am J Reprod Immunol</addtitle><description>Recent progress in lipid research has unveiled new biologic roles for lysophospholipids as mediators of intercellular signaling. Lysophosphatidic acid (LPA) and sphingosine 1‐phosphate (S1P) are representative lysophospholipids. Accumulating evidence suggests that, acting as intercellular mediators, these and other lysophospholipids may play important roles in physiological and pathological situations. This review discusses the possible involvement of LPA and S1P in reproductive processes, with a focus on the regulatory mechanisms of pregnancy maintenance. As LPA promotes prostaglandin synthesis, mediators in the LPA pathway may also play a significant role in implantation and parturition. S1P signaling is thought to be essential in vascular formation within the uteroplacental unit and in fetomaternal immunologic interactions. Derangements in either one of these lysophospholipid signaling pathways could result in pregnancy complications that may include implantation failure, preeclampsia, and preterm labor.</description><subject>Endometrium - immunology</subject><subject>Endometrium - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Lysophosphatidic acid</subject><subject>lysophospholipid</subject><subject>Lysophospholipids - immunology</subject><subject>Lysophospholipids - metabolism</subject><subject>Maternal-Fetal Exchange - immunology</subject><subject>Medical research</subject><subject>Neovascularization, Physiologic</subject><subject>Obstetric Labor, Premature - immunology</subject><subject>Obstetric Labor, Premature - metabolism</subject><subject>Obstetric Labor, Premature - pathology</subject><subject>Ovary - immunology</subject><subject>Ovary - metabolism</subject><subject>Parturition - immunology</subject><subject>Placenta - blood supply</subject><subject>Placenta - immunology</subject><subject>Placenta - metabolism</subject><subject>Pre-Eclampsia - immunology</subject><subject>Pre-Eclampsia - metabolism</subject><subject>Pre-Eclampsia - pathology</subject><subject>Pregnancy</subject><subject>Pregnancy - immunology</subject><subject>Prostaglandins - biosynthesis</subject><subject>Prostaglandins - immunology</subject><subject>reproduction</subject><subject>Signal Transduction</subject><subject>Sphingosine - analogs & derivatives</subject><subject>Sphingosine - immunology</subject><subject>Sphingosine - metabolism</subject><subject>sphingosine 1-phosphate</subject><issn>1046-7408</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1rGzEQhkVJaRInh_6BspBLc1hH39L2FvLp4CTGaQnkIrS7s67c9cqVbFr_-8h14kOgEMGgYfTMA3oR-kxwn6RzYqeuTyhlxQe0RyTGOdaF2kk95jJXHOtdtB_jFOM0Z-oT2qVc6kJwtYe-XcwgTFw3yca-hZg1PmTDVfTznz6mat3c1dkt1M4ufIiZ67JRgElnu2p1gD42to1w-HL30I_Li-9n1_nw_mpwdjrMKyFxkduC1FISRXVDFaulFgqo0A0BDhWvqCxLTCktoRDMllpjqtN7pQQoyq2wrIe-brzz4H8vIS7MzMUK2tZ24JfRECGIZFRi_g6UK0EKrmhCj96gU78MXfrImhI4KSVL1PGGqoKPMUBj5sHNbFgZgs06e5OyN_-yT-yXF-OynEG9JV_DTsDJBvjjWlj932RObwavynyz4eIC_m43bPhlpGJKmMe7K3P-MB6P5NOtKdgzEJ-Z7Q</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>Nagamatsu, Takeshi</creator><creator>Iwasawa-Kawai, Yuki</creator><creator>Ichikawa, Mayuko</creator><creator>Kawana, Kei</creator><creator>Yamashita, Takahiro</creator><creator>Osuga, Yutaka</creator><creator>Fujii, Tomoyuki</creator><creator>Schust, Danny J.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201408</creationdate><title>Emerging Roles for Lysophospholipid Mediators in Pregnancy</title><author>Nagamatsu, Takeshi ; Iwasawa-Kawai, Yuki ; Ichikawa, Mayuko ; Kawana, Kei ; Yamashita, Takahiro ; Osuga, Yutaka ; Fujii, Tomoyuki ; Schust, Danny J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5609-a91d661728f273d6857e258f1e4ec4c26bb0222be953ab88028e25c75e724a5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Endometrium - immunology</topic><topic>Endometrium - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Lysophosphatidic acid</topic><topic>lysophospholipid</topic><topic>Lysophospholipids - immunology</topic><topic>Lysophospholipids - metabolism</topic><topic>Maternal-Fetal Exchange - immunology</topic><topic>Medical research</topic><topic>Neovascularization, Physiologic</topic><topic>Obstetric Labor, Premature - immunology</topic><topic>Obstetric Labor, Premature - metabolism</topic><topic>Obstetric Labor, Premature - pathology</topic><topic>Ovary - immunology</topic><topic>Ovary - metabolism</topic><topic>Parturition - immunology</topic><topic>Placenta - blood supply</topic><topic>Placenta - immunology</topic><topic>Placenta - metabolism</topic><topic>Pre-Eclampsia - immunology</topic><topic>Pre-Eclampsia - metabolism</topic><topic>Pre-Eclampsia - pathology</topic><topic>Pregnancy</topic><topic>Pregnancy - immunology</topic><topic>Prostaglandins - biosynthesis</topic><topic>Prostaglandins - immunology</topic><topic>reproduction</topic><topic>Signal Transduction</topic><topic>Sphingosine - analogs & derivatives</topic><topic>Sphingosine - immunology</topic><topic>Sphingosine - metabolism</topic><topic>sphingosine 1-phosphate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagamatsu, Takeshi</creatorcontrib><creatorcontrib>Iwasawa-Kawai, Yuki</creatorcontrib><creatorcontrib>Ichikawa, Mayuko</creatorcontrib><creatorcontrib>Kawana, Kei</creatorcontrib><creatorcontrib>Yamashita, Takahiro</creatorcontrib><creatorcontrib>Osuga, Yutaka</creatorcontrib><creatorcontrib>Fujii, Tomoyuki</creatorcontrib><creatorcontrib>Schust, Danny J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagamatsu, Takeshi</au><au>Iwasawa-Kawai, Yuki</au><au>Ichikawa, Mayuko</au><au>Kawana, Kei</au><au>Yamashita, Takahiro</au><au>Osuga, Yutaka</au><au>Fujii, Tomoyuki</au><au>Schust, Danny J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emerging Roles for Lysophospholipid Mediators in Pregnancy</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><addtitle>Am J Reprod Immunol</addtitle><date>2014-08</date><risdate>2014</risdate><volume>72</volume><issue>2</issue><spage>182</spage><epage>191</epage><pages>182-191</pages><issn>1046-7408</issn><eissn>1600-0897</eissn><abstract>Recent progress in lipid research has unveiled new biologic roles for lysophospholipids as mediators of intercellular signaling. Lysophosphatidic acid (LPA) and sphingosine 1‐phosphate (S1P) are representative lysophospholipids. Accumulating evidence suggests that, acting as intercellular mediators, these and other lysophospholipids may play important roles in physiological and pathological situations. This review discusses the possible involvement of LPA and S1P in reproductive processes, with a focus on the regulatory mechanisms of pregnancy maintenance. As LPA promotes prostaglandin synthesis, mediators in the LPA pathway may also play a significant role in implantation and parturition. S1P signaling is thought to be essential in vascular formation within the uteroplacental unit and in fetomaternal immunologic interactions. Derangements in either one of these lysophospholipid signaling pathways could result in pregnancy complications that may include implantation failure, preeclampsia, and preterm labor.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>24689547</pmid><doi>10.1111/aji.12239</doi><tpages>10</tpages></addata></record> |
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| subjects | Endometrium - immunology Endometrium - metabolism Female Humans Lysophosphatidic acid lysophospholipid Lysophospholipids - immunology Lysophospholipids - metabolism Maternal-Fetal Exchange - immunology Medical research Neovascularization, Physiologic Obstetric Labor, Premature - immunology Obstetric Labor, Premature - metabolism Obstetric Labor, Premature - pathology Ovary - immunology Ovary - metabolism Parturition - immunology Placenta - blood supply Placenta - immunology Placenta - metabolism Pre-Eclampsia - immunology Pre-Eclampsia - metabolism Pre-Eclampsia - pathology Pregnancy Pregnancy - immunology Prostaglandins - biosynthesis Prostaglandins - immunology reproduction Signal Transduction Sphingosine - analogs & derivatives Sphingosine - immunology Sphingosine - metabolism sphingosine 1-phosphate |
| title | Emerging Roles for Lysophospholipid Mediators in Pregnancy |
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