Left-right patterning: conserved and divergent mechanisms
The left-right (LR) asymmetry of visceral organs is fundamental to their function and position within the body. Over the past decade or so, the molecular mechanisms underlying the establishment of such LR asymmetry have been revealed in many vertebrate and invertebrate model organisms. These studies...
Gespeichert in:
| Veröffentlicht in: | Development (Cambridge) 2012-09, Vol.139 (18), p.3257-3262 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3262 |
|---|---|
| container_issue | 18 |
| container_start_page | 3257 |
| container_title | Development (Cambridge) |
| container_volume | 139 |
| creator | Nakamura, Tetsuya Hamada, Hiroshi |
| description | The left-right (LR) asymmetry of visceral organs is fundamental to their function and position within the body. Over the past decade or so, the molecular mechanisms underlying the establishment of such LR asymmetry have been revealed in many vertebrate and invertebrate model organisms. These studies have identified a gene network that contributes to this process and is highly conserved from sea urchin to mouse. By contrast, some specific steps of the process, such as the symmetry-breaking event and situs-specific organogenesis, appear to have diverged during evolution. Here, we summarize the common and divergent mechanisms by which LR asymmetry is established in vertebrates. |
| doi_str_mv | 10.1242/dev.061606 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1551630935</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1551630935</sourcerecordid><originalsourceid>FETCH-LOGICAL-c422t-467e2be498821bec6434dcdcbf30574998ef47c59054d6840ad96663ca6a719a3</originalsourceid><addsrcrecordid>eNqF0M1Kw0AUhuFBFFurGy9AshQhdf4nx50U_6DgRtdhMnPSRppJnUkL3n1TWt26-jYP3-Il5JrRKeOS33vcTqlmmuoTMmbSmBwYh1MypqBozgDYiFyk9EUpFdqYczLifBCSwpjAHOs-j81i2Wdr2_cYQxMWD5nrQsK4RZ_Z4DPfbDEuMPRZi25pQ5PadEnOartKeHXcCfl8fvqYvebz95e32eM8d5LzPpfaIK9QQlFwVqHTUkjvvKtqQZWRAAXW0jgFVEmvC0mtB621cFZbw8CKCbk9_K5j973B1JdtkxyuVjZgt0klU4ppQUGo_ykVsthXMAO9O1AXu5Qi1uU6Nq2NPwMq91XLoWp5qDrgm-PvpmrR_9HfjGIHGLpxAw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1034800037</pqid></control><display><type>article</type><title>Left-right patterning: conserved and divergent mechanisms</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>Company of Biologists</source><creator>Nakamura, Tetsuya ; Hamada, Hiroshi</creator><creatorcontrib>Nakamura, Tetsuya ; Hamada, Hiroshi</creatorcontrib><description>The left-right (LR) asymmetry of visceral organs is fundamental to their function and position within the body. Over the past decade or so, the molecular mechanisms underlying the establishment of such LR asymmetry have been revealed in many vertebrate and invertebrate model organisms. These studies have identified a gene network that contributes to this process and is highly conserved from sea urchin to mouse. By contrast, some specific steps of the process, such as the symmetry-breaking event and situs-specific organogenesis, appear to have diverged during evolution. Here, we summarize the common and divergent mechanisms by which LR asymmetry is established in vertebrates.</description><identifier>ISSN: 0950-1991</identifier><identifier>EISSN: 1477-9129</identifier><identifier>DOI: 10.1242/dev.061606</identifier><identifier>PMID: 22912409</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Body Patterning - physiology ; Cell Movement - genetics ; Cell Movement - physiology ; Echinoidea ; Gene Expression Regulation, Developmental ; Invertebrates - embryology ; Invertebrates - growth & development ; Mice ; Sea Urchins - embryology ; Sea Urchins - growth & development ; Vertebrates - embryology ; Vertebrates - growth & development</subject><ispartof>Development (Cambridge), 2012-09, Vol.139 (18), p.3257-3262</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-467e2be498821bec6434dcdcbf30574998ef47c59054d6840ad96663ca6a719a3</citedby><cites>FETCH-LOGICAL-c422t-467e2be498821bec6434dcdcbf30574998ef47c59054d6840ad96663ca6a719a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,3667,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22912409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakamura, Tetsuya</creatorcontrib><creatorcontrib>Hamada, Hiroshi</creatorcontrib><title>Left-right patterning: conserved and divergent mechanisms</title><title>Development (Cambridge)</title><addtitle>Development</addtitle><description>The left-right (LR) asymmetry of visceral organs is fundamental to their function and position within the body. Over the past decade or so, the molecular mechanisms underlying the establishment of such LR asymmetry have been revealed in many vertebrate and invertebrate model organisms. These studies have identified a gene network that contributes to this process and is highly conserved from sea urchin to mouse. By contrast, some specific steps of the process, such as the symmetry-breaking event and situs-specific organogenesis, appear to have diverged during evolution. Here, we summarize the common and divergent mechanisms by which LR asymmetry is established in vertebrates.</description><subject>Animals</subject><subject>Body Patterning - physiology</subject><subject>Cell Movement - genetics</subject><subject>Cell Movement - physiology</subject><subject>Echinoidea</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Invertebrates - embryology</subject><subject>Invertebrates - growth & development</subject><subject>Mice</subject><subject>Sea Urchins - embryology</subject><subject>Sea Urchins - growth & development</subject><subject>Vertebrates - embryology</subject><subject>Vertebrates - growth & development</subject><issn>0950-1991</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M1Kw0AUhuFBFFurGy9AshQhdf4nx50U_6DgRtdhMnPSRppJnUkL3n1TWt26-jYP3-Il5JrRKeOS33vcTqlmmuoTMmbSmBwYh1MypqBozgDYiFyk9EUpFdqYczLifBCSwpjAHOs-j81i2Wdr2_cYQxMWD5nrQsK4RZ_Z4DPfbDEuMPRZi25pQ5PadEnOartKeHXcCfl8fvqYvebz95e32eM8d5LzPpfaIK9QQlFwVqHTUkjvvKtqQZWRAAXW0jgFVEmvC0mtB621cFZbw8CKCbk9_K5j973B1JdtkxyuVjZgt0klU4ppQUGo_ykVsthXMAO9O1AXu5Qi1uU6Nq2NPwMq91XLoWp5qDrgm-PvpmrR_9HfjGIHGLpxAw</recordid><startdate>20120915</startdate><enddate>20120915</enddate><creator>Nakamura, Tetsuya</creator><creator>Hamada, Hiroshi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20120915</creationdate><title>Left-right patterning: conserved and divergent mechanisms</title><author>Nakamura, Tetsuya ; Hamada, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-467e2be498821bec6434dcdcbf30574998ef47c59054d6840ad96663ca6a719a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Body Patterning - physiology</topic><topic>Cell Movement - genetics</topic><topic>Cell Movement - physiology</topic><topic>Echinoidea</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Invertebrates - embryology</topic><topic>Invertebrates - growth & development</topic><topic>Mice</topic><topic>Sea Urchins - embryology</topic><topic>Sea Urchins - growth & development</topic><topic>Vertebrates - embryology</topic><topic>Vertebrates - growth & development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakamura, Tetsuya</creatorcontrib><creatorcontrib>Hamada, Hiroshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakamura, Tetsuya</au><au>Hamada, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Left-right patterning: conserved and divergent mechanisms</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>2012-09-15</date><risdate>2012</risdate><volume>139</volume><issue>18</issue><spage>3257</spage><epage>3262</epage><pages>3257-3262</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>The left-right (LR) asymmetry of visceral organs is fundamental to their function and position within the body. Over the past decade or so, the molecular mechanisms underlying the establishment of such LR asymmetry have been revealed in many vertebrate and invertebrate model organisms. These studies have identified a gene network that contributes to this process and is highly conserved from sea urchin to mouse. By contrast, some specific steps of the process, such as the symmetry-breaking event and situs-specific organogenesis, appear to have diverged during evolution. Here, we summarize the common and divergent mechanisms by which LR asymmetry is established in vertebrates.</abstract><cop>England</cop><pmid>22912409</pmid><doi>10.1242/dev.061606</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-1991 |
| ispartof | Development (Cambridge), 2012-09, Vol.139 (18), p.3257-3262 |
| issn | 0950-1991 1477-9129 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1551630935 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Animals Body Patterning - physiology Cell Movement - genetics Cell Movement - physiology Echinoidea Gene Expression Regulation, Developmental Invertebrates - embryology Invertebrates - growth & development Mice Sea Urchins - embryology Sea Urchins - growth & development Vertebrates - embryology Vertebrates - growth & development |
| title | Left-right patterning: conserved and divergent mechanisms |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T21%3A28%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Left-right%20patterning:%20conserved%20and%20divergent%20mechanisms&rft.jtitle=Development%20(Cambridge)&rft.au=Nakamura,%20Tetsuya&rft.date=2012-09-15&rft.volume=139&rft.issue=18&rft.spage=3257&rft.epage=3262&rft.pages=3257-3262&rft.issn=0950-1991&rft.eissn=1477-9129&rft_id=info:doi/10.1242/dev.061606&rft_dat=%3Cproquest_cross%3E1551630935%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1034800037&rft_id=info:pmid/22912409&rfr_iscdi=true |