HLA class II molecules influence susceptibility versus protection in inflammatory diseases by determining the cytokine profile

The MHC in humans encodes the most polymorphic genes, the HLA genes, which are critical for the immune system to clear infection. This can be attributed to strong selection pressure as populations moved to different parts of the world and encountered new kinds of infections, leading to new HLA class...

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Veröffentlicht in:The Journal of immunology (1950) 2013-01, Vol.190 (2), p.513-519
Hauptverfasser: Mangalam, Ashutosh K, Taneja, Veena, David, Chella S
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Sprache:eng
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