EBI2 regulates CXCL13‐mediated responses by heterodimerization with CXCR5

B‐cell movement into lymphoid follicles depends on the expression of the chemokine receptor CXCR5 and the recently reported Epstein‐Barr virus‐induced receptor 2 (EBI2). In cooperation with CXCR5, EBI2 helps to position activated B cells in the follicle, although the mechanism is poorly understood....

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Veröffentlicht in:	The FASEB journal 2012-12, Vol.26 (12), p.4841-4854
Hauptverfasser:	Barroso, Rubén, Muñoz, Laura Martínez, Barrondo, Sergio, Vega, Beatriz, Holgado, Borja L., Lucas, Pilar, Baíllo, Amparo, Sallés, Joan, Rodríguez‐Frade, José M., Mellado, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - metabolism binding affinity Binding, Competitive Blotting, Western Cell Movement Cells, Cultured Chemokine CXCL13 - genetics Chemokine CXCL13 - metabolism Fluorescence Resonance Energy Transfer Guanosine 5'-O-(3-Thiotriphosphate) - metabolism Gαi activation HEK293 Cells Humans Kinetics Luminescent Proteins - genetics Luminescent Proteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout modulation of the B‐cell response Protein Multimerization Radioligand Assay Receptors, CXCR5 - chemistry Receptors, CXCR5 - genetics Receptors, CXCR5 - metabolism Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Transfection
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