Consumption of cranberry beverage improved endogenous antioxidant status and protected against bacteria adhesion in healthy humans: a randomized controlled trial
Abstract Consumption of polyphenol-rich foods is associated with lower risk from many chronic diseases. We hypothesized that a single dose of cranberry beverage would improve indices of oxidative stress, inflammation, and urinary antibacterial adhesion activity in healthy humans. Six males and 6 fem...
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| Veröffentlicht in: | Nutrition research (New York, N.Y.) N.Y.), 2014-05, Vol.34 (5), p.420-427 |
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| creator | Mathison, Bridget D Kimble, Lindsey L Kaspar, Kerrie L Khoo, Christina Chew, Boon P |
| description | Abstract Consumption of polyphenol-rich foods is associated with lower risk from many chronic diseases. We hypothesized that a single dose of cranberry beverage would improve indices of oxidative stress, inflammation, and urinary antibacterial adhesion activity in healthy humans. Six males and 6 females (18-35 years; body mass index, 19-25 kg/m2 ) consumed placebo, cranberry leaf extract beverage, or low-calorie cranberry juice cocktail (LCJC) once in a randomized, double-blind, placebo-controlled cross-over experimental design trial. The washout period between beverages was 1 week. Blood was collected 0, 2, 4, 8, and 24 hours after beverage consumption for measuring oxidative and inflammatory biomarkers. Urine was collected at 0, 0 to 3, 3 to 6, 6 to 9, 9 to 12, and 24 hours postintervention to assess antibacterial adhesion activity. Consumption of cranberry leaf extract beverage elevated ( P < .05) blood glutathione peroxidase activity, whereas LCJC consumption increased ( P < .05) glutathione concentrations and superoxide dismutase activity compared with placebo. Cranberry leaf extract beverage and LCJC consumption had no effect on the inflammatory biomarkers measured as compared with placebo. At 0 to 3 hours postconsumption, urine from participants who consumed cranberry beverages had higher ( P < .05) ex vivo antiadhesion activity against P-fimbriated Escherichia coli compared with placebo. An acute dose of cranberry beverages improved biomarkers of antioxidant status and inhibition of bacterial adhesion in urine. |
| doi_str_mv | 10.1016/j.nutres.2014.03.006 |
| format | Article |
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We hypothesized that a single dose of cranberry beverage would improve indices of oxidative stress, inflammation, and urinary antibacterial adhesion activity in healthy humans. Six males and 6 females (18-35 years; body mass index, 19-25 kg/m2 ) consumed placebo, cranberry leaf extract beverage, or low-calorie cranberry juice cocktail (LCJC) once in a randomized, double-blind, placebo-controlled cross-over experimental design trial. The washout period between beverages was 1 week. Blood was collected 0, 2, 4, 8, and 24 hours after beverage consumption for measuring oxidative and inflammatory biomarkers. Urine was collected at 0, 0 to 3, 3 to 6, 6 to 9, 9 to 12, and 24 hours postintervention to assess antibacterial adhesion activity. Consumption of cranberry leaf extract beverage elevated ( P < .05) blood glutathione peroxidase activity, whereas LCJC consumption increased ( P < .05) glutathione concentrations and superoxide dismutase activity compared with placebo. Cranberry leaf extract beverage and LCJC consumption had no effect on the inflammatory biomarkers measured as compared with placebo. At 0 to 3 hours postconsumption, urine from participants who consumed cranberry beverages had higher ( P < .05) ex vivo antiadhesion activity against P-fimbriated Escherichia coli compared with placebo. An acute dose of cranberry beverages improved biomarkers of antioxidant status and inhibition of bacterial adhesion in urine.</description><identifier>ISSN: 0271-5317</identifier><identifier>EISSN: 1879-0739</identifier><identifier>DOI: 10.1016/j.nutres.2014.03.006</identifier><identifier>PMID: 24916555</identifier><identifier>CODEN: NTRSDC</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Anti-Bacterial Agents - pharmacology ; Antioxidants - metabolism ; Antioxidants - pharmacology ; Bacterial adhesion ; Bacterial Adhesion - drug effects ; Beverages ; Biological and medical sciences ; Cross-Over Studies ; Double-Blind Method ; Escherichia coli ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology and Hepatology ; Glutathione - blood ; Glutathione Peroxidase - blood ; Humans ; Inflammation ; Male ; Oxidative stress ; Oxidative Stress - drug effects ; Plant Leaves ; Plant Preparations - pharmacology ; Polyphenols - pharmacology ; Reference Values ; Superoxide Dismutase - blood ; Vaccinium macrocarpon ; Vaccinium macrocarpon - chemistry ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Nutrition research (New York, N.Y.), 2014-05, Vol.34 (5), p.420-427</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier Inc. 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We hypothesized that a single dose of cranberry beverage would improve indices of oxidative stress, inflammation, and urinary antibacterial adhesion activity in healthy humans. Six males and 6 females (18-35 years; body mass index, 19-25 kg/m2 ) consumed placebo, cranberry leaf extract beverage, or low-calorie cranberry juice cocktail (LCJC) once in a randomized, double-blind, placebo-controlled cross-over experimental design trial. The washout period between beverages was 1 week. Blood was collected 0, 2, 4, 8, and 24 hours after beverage consumption for measuring oxidative and inflammatory biomarkers. Urine was collected at 0, 0 to 3, 3 to 6, 6 to 9, 9 to 12, and 24 hours postintervention to assess antibacterial adhesion activity. Consumption of cranberry leaf extract beverage elevated ( P < .05) blood glutathione peroxidase activity, whereas LCJC consumption increased ( P < .05) glutathione concentrations and superoxide dismutase activity compared with placebo. Cranberry leaf extract beverage and LCJC consumption had no effect on the inflammatory biomarkers measured as compared with placebo. At 0 to 3 hours postconsumption, urine from participants who consumed cranberry beverages had higher ( P < .05) ex vivo antiadhesion activity against P-fimbriated Escherichia coli compared with placebo. An acute dose of cranberry beverages improved biomarkers of antioxidant status and inhibition of bacterial adhesion in urine.</description><subject>Adult</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - pharmacology</subject><subject>Bacterial adhesion</subject><subject>Bacterial Adhesion - drug effects</subject><subject>Beverages</subject><subject>Biological and medical sciences</subject><subject>Cross-Over Studies</subject><subject>Double-Blind Method</subject><subject>Escherichia coli</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology and Hepatology</subject><subject>Glutathione - blood</subject><subject>Glutathione Peroxidase - blood</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Male</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Plant Leaves</subject><subject>Plant Preparations - pharmacology</subject><subject>Polyphenols - pharmacology</subject><subject>Reference Values</subject><subject>Superoxide Dismutase - blood</subject><subject>Vaccinium macrocarpon</subject><subject>Vaccinium macrocarpon - chemistry</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0271-5317</issn><issn>1879-0739</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksGO0zAQhiMEYruFN0DIFyQuLXYcOwkHpFXFAtJKHICzNbEnrUtiF9upKG_Dm-LQAhIXOI1t_f-MZ74piieMrhll8sV-7aYUMK5Lyqo15WtK5b1iwZq6XdGat_eLBS1rthKc1VfFdYx7SlnNOH9YXJVVy6QQYlF833gXp_GQrHfE90QHcB2GcCIdHjHAFokdD8Ef0RB0xm_R-SkScNnw1ZocSUyQfj4ZkoUJdcpa2IJ1MZEO8jVYIGB2GOci1pEdwpB2J7KbRnDxJQGSqxo_2m_Zqb1LwQ9DPqZsHB4VD3oYIj6-xGXx6fb1x83b1d37N-82N3crLSqZVqaR2JpOlAjAZdPQspF9Q5FVRjddS0G3ugKtK9maFkGUfdc3QqNkrGPISr4snp_z5ia-TBiTGm3UOAzgMLesmBBMlq3k4j-kXJRUymrOWp2lOvgYA_bqEOwI4aQYVTNHtVdnjmrmqChXmWO2Pb1UmLoRzW_TL3BZ8OwigKhh6PMAtY1_dI2kss60l8Wrsw7z6I4Wg4raotNobMiklPH2Xz_5O4EerLO55mc8Ydz7KbiMRTEVS0XVh3nn5pVjFaW0qgX_Ad-W12M</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Mathison, Bridget D</creator><creator>Kimble, Lindsey L</creator><creator>Kaspar, Kerrie L</creator><creator>Khoo, Christina</creator><creator>Chew, Boon P</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20140501</creationdate><title>Consumption of cranberry beverage improved endogenous antioxidant status and protected against bacteria adhesion in healthy humans: a randomized controlled trial</title><author>Mathison, Bridget D ; Kimble, Lindsey L ; Kaspar, Kerrie L ; Khoo, Christina ; Chew, Boon P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c546t-d86e9db52eaa36880286f80e14dc8b90ac9c4acc469d9ea52fbf85ce611b1e123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antioxidants - metabolism</topic><topic>Antioxidants - pharmacology</topic><topic>Bacterial adhesion</topic><topic>Bacterial Adhesion - drug effects</topic><topic>Beverages</topic><topic>Biological and medical sciences</topic><topic>Cross-Over Studies</topic><topic>Double-Blind Method</topic><topic>Escherichia coli</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology and Hepatology</topic><topic>Glutathione - blood</topic><topic>Glutathione Peroxidase - blood</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Male</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Plant Leaves</topic><topic>Plant Preparations - pharmacology</topic><topic>Polyphenols - pharmacology</topic><topic>Reference Values</topic><topic>Superoxide Dismutase - blood</topic><topic>Vaccinium macrocarpon</topic><topic>Vaccinium macrocarpon - chemistry</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mathison, Bridget D</creatorcontrib><creatorcontrib>Kimble, Lindsey L</creatorcontrib><creatorcontrib>Kaspar, Kerrie L</creatorcontrib><creatorcontrib>Khoo, Christina</creatorcontrib><creatorcontrib>Chew, Boon P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Nutrition research (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mathison, Bridget D</au><au>Kimble, Lindsey L</au><au>Kaspar, Kerrie L</au><au>Khoo, Christina</au><au>Chew, Boon P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Consumption of cranberry beverage improved endogenous antioxidant status and protected against bacteria adhesion in healthy humans: a randomized controlled trial</atitle><jtitle>Nutrition research (New York, N.Y.)</jtitle><addtitle>Nutr Res</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>34</volume><issue>5</issue><spage>420</spage><epage>427</epage><pages>420-427</pages><issn>0271-5317</issn><eissn>1879-0739</eissn><coden>NTRSDC</coden><abstract>Abstract Consumption of polyphenol-rich foods is associated with lower risk from many chronic diseases. We hypothesized that a single dose of cranberry beverage would improve indices of oxidative stress, inflammation, and urinary antibacterial adhesion activity in healthy humans. Six males and 6 females (18-35 years; body mass index, 19-25 kg/m2 ) consumed placebo, cranberry leaf extract beverage, or low-calorie cranberry juice cocktail (LCJC) once in a randomized, double-blind, placebo-controlled cross-over experimental design trial. The washout period between beverages was 1 week. Blood was collected 0, 2, 4, 8, and 24 hours after beverage consumption for measuring oxidative and inflammatory biomarkers. Urine was collected at 0, 0 to 3, 3 to 6, 6 to 9, 9 to 12, and 24 hours postintervention to assess antibacterial adhesion activity. Consumption of cranberry leaf extract beverage elevated ( P < .05) blood glutathione peroxidase activity, whereas LCJC consumption increased ( P < .05) glutathione concentrations and superoxide dismutase activity compared with placebo. Cranberry leaf extract beverage and LCJC consumption had no effect on the inflammatory biomarkers measured as compared with placebo. At 0 to 3 hours postconsumption, urine from participants who consumed cranberry beverages had higher ( P < .05) ex vivo antiadhesion activity against P-fimbriated Escherichia coli compared with placebo. An acute dose of cranberry beverages improved biomarkers of antioxidant status and inhibition of bacterial adhesion in urine.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>24916555</pmid><doi>10.1016/j.nutres.2014.03.006</doi><tpages>8</tpages></addata></record> |
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| ispartof | Nutrition research (New York, N.Y.), 2014-05, Vol.34 (5), p.420-427 |
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| subjects | Adult Anti-Bacterial Agents - pharmacology Antioxidants - metabolism Antioxidants - pharmacology Bacterial adhesion Bacterial Adhesion - drug effects Beverages Biological and medical sciences Cross-Over Studies Double-Blind Method Escherichia coli Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology and Hepatology Glutathione - blood Glutathione Peroxidase - blood Humans Inflammation Male Oxidative stress Oxidative Stress - drug effects Plant Leaves Plant Preparations - pharmacology Polyphenols - pharmacology Reference Values Superoxide Dismutase - blood Vaccinium macrocarpon Vaccinium macrocarpon - chemistry Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Consumption of cranberry beverage improved endogenous antioxidant status and protected against bacteria adhesion in healthy humans: a randomized controlled trial |
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