Assessment of the antigen-specific antibody response induced by mucosal administration of a GnRH conjugate entrapped in lipid nanoparticles

Abstract Vaccines administered parenterally have been developed against gonadotrophin-releasing hormone (GnRH) for anti-fertility and anti-cancer purposes. The aim of this study was to demonstrate whether mucosal delivery using GnRH immunogens entrapped in lipid nanoparticles (LNP) could induce anti...

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Veröffentlicht in:	Nanomedicine 2014-07, Vol.10 (5), p.e971-e979
Hauptverfasser:	Gebril, Ayman M., BVSc, Lamprou, Dimitrios A., PhD, Alsaadi, Manal M., PhD, Stimson, William H., PhD, Mullen, Alexander B., PhD, Ferro, Valerie A., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Mucosal Animals Antibody Formation - immunology Atomic force microscopy Bilosomes Female Gonadotrophin-releasing hormone Gonadotropin-Releasing Hormone - chemistry Gonadotropin-Releasing Hormone - immunology Humans Internal Medicine Mice Mice, Inbred BALB C Microscopy, Atomic Force Nanoparticles - administration & dosage Nanoparticles - chemistry Non-ionic surfactant vesicles Pyrrolidonecarboxylic Acid - analogs & derivatives Pyrrolidonecarboxylic Acid - chemistry Pyrrolidonecarboxylic Acid - immunology
Online-Zugang:	Volltext
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