Exosome release of ADAM15 and the functional implications of human macrophage‐derived ADAM15 exosomes

ABSTRACT A disintegrin and metalloproteinase 15 (ADAM15), the only ADAM protein containing an Arg‐Gly‐Asp (RGD) motif in its disintegrin‐like domain, is a widely expressed membrane protein that is involved in tumor progression and suppression. However, the underlying mechanism of ADAM15‐mediated tum...

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Veröffentlicht in:	The FASEB journal 2012-07, Vol.26 (7), p.3084-3095
Hauptverfasser:	Lee, Hee Doo, Koo, Bon‐Hun, Kim, Yeon Hyang, Jeon, Ok‐Hee, Kim, Doo‐Sik
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - genetics ADAM Proteins - immunology ADAM Proteins - metabolism Animals antitumor immunity Base Sequence Cell Line, Tumor Cell Movement Cell Proliferation disintegrin DNA, Complementary - genetics Exocytosis Exosomes - drug effects Exosomes - metabolism Female Humans Integrin alphaVbeta3 - metabolism Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Membrane Proteins - genetics Membrane Proteins - immunology Membrane Proteins - metabolism Mice Mice, Inbred BALB C Mice, Nude microvesicles Protein Kinase C - metabolism Tetradecanoylphorbol Acetate - pharmacology Transplantation, Heterologous Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - immunology Tumor Suppressor Proteins - metabolism Vitronectin - metabolism
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