Modulation of binding properties of amphiphilic DNA containing multiple dodecyl phosphotriester linkages to lipid bilayer membrane
DNA is a promising functional molecule to modify and design lipid membrane functions. In order to use DNA in a hydrophilic-hydrophobic interface including lipid membrane, we have developed an amphiphilic DNA having dodecyl phosphotriester linkages (dod-DNA). Herein, we report the binding of a series...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2014-08, Vol.24 (15), p.3578-3581 |
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| container_end_page | 3581 |
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| container_issue | 15 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Makishi, Shingo Shibata, Tomonori Okazaki, Masatsugu Dohno, Chikara Nakatani, Kazuhiko |
| description | DNA is a promising functional molecule to modify and design lipid membrane functions. In order to use DNA in a hydrophilic-hydrophobic interface including lipid membrane, we have developed an amphiphilic DNA having dodecyl phosphotriester linkages (dod-DNA). Herein, we report the binding of a series of amphiphilic dod-DNAs to the lipid bilayer membrane. Surface plasmon resonance (SPR) assay and fluorescent microscopy showed that dod-DNA having three dodecyl groups at each end strongly bound to lipid membrane due to the slow dissociation rate and the dod-DNA can be used as a linear template for molecular arrangement on the membrane surface. |
| doi_str_mv | 10.1016/j.bmcl.2014.05.042 |
| format | Article |
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In order to use DNA in a hydrophilic-hydrophobic interface including lipid membrane, we have developed an amphiphilic DNA having dodecyl phosphotriester linkages (dod-DNA). Herein, we report the binding of a series of amphiphilic dod-DNAs to the lipid bilayer membrane. 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| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 2014-08, Vol.24 (15), p.3578-3581 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Binding Sites DNA - chemistry Lipid Bilayers - chemistry Organophosphates - chemistry Surface Plasmon Resonance Surface-Active Agents - chemistry |
| title | Modulation of binding properties of amphiphilic DNA containing multiple dodecyl phosphotriester linkages to lipid bilayer membrane |
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