IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice

The pleiotropic cytokine IL-21 is implicated in the pathogenesis of human systemic lupus erythematosus by polymorphisms in the molecule and its receptor (IL-21R). The systemic lupus erythematosus-like autoimmune disease of BXSB.Yaa mice is critically dependent on IL-21 signaling, providing a model f...

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Veröffentlicht in:	The Journal of immunology (1950) 2013-11, Vol.191 (9), p.4581-4588
Hauptverfasser:	McPhee, Caroline G, Bubier, Jason A, Sproule, Thomas J, Park, Giljun, Steinbuck, Martin P, Schott, William H, Christianson, Gregory J, Morse, 3rd, Herbert C, Roopenian, Derry C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - immunology Cytokines - biosynthesis Interleukins - genetics Interleukins - metabolism Lupus Erythematosus, Systemic - immunology Male Mice Mice, Transgenic Receptors, Interleukin-21 - genetics Receptors, Interleukin-21 - metabolism Signal Transduction - immunology
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