The downregulation of microRNA let-7a contributes to the excessive expression of type I collagen in systemic and localized scleroderma

Systemic and localized scleroderma (SSc and LSc) is characterized by excessive deposition of collagen and tissue fibrosis in the skin. Although they have fundamental common characteristics including autoimmunity, little is known about the exact mechanism that mediates the excessive collagen expressi...

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Veröffentlicht in:	The Journal of immunology (1950) 2013-04, Vol.190 (8), p.3905-3915
Hauptverfasser:	Makino, Katsunari, Jinnin, Masatoshi, Hirano, Ayaka, Yamane, Keitaro, Eto, Mitsuhiko, Kusano, Takamitsu, Honda, Noritoshi, Kajihara, Ikko, Makino, Takamitsu, Sakai, Keisuke, Masuguchi, Shinichi, Fukushima, Satoshi, Ihn, Hironobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Collagen Type I - biosynthesis Collagen Type I - genetics Collagen Type I - metabolism Down-Regulation - immunology Humans MicroRNAs - antagonists & inhibitors MicroRNAs - biosynthesis MicroRNAs - physiology Scleroderma, Systemic - immunology Scleroderma, Systemic - metabolism Scleroderma, Systemic - pathology Skin - immunology Skin - metabolism Skin - pathology Up-Regulation - immunology
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