TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors

Review of the intracellular pathway of TREM‐1 signaling, its interactions with PRR pathways, focusing on TLRs and NLRs. TREM‐1 is an important signaling receptor expressed on neutrophils and monocytes that plays an important role in systemic infections. Here, we review the intracellular signaling pa...

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Veröffentlicht in:	Journal of leukocyte biology 2013-02, Vol.93 (2), p.209-215
Hauptverfasser:	Arts, Rob J. W., Joosten, Leo A. B., Meer, Jos W. M., Netea, Mihai G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DAP12 Humans Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism myeloid cells NLR Receptors, Immunologic - immunology Receptors, Immunologic - metabolism Receptors, Pattern Recognition - immunology Receptors, Pattern Recognition - metabolism Signal Transduction - immunology signaling cascade TLR Triggering Receptor Expressed on Myeloid Cells-1
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