TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors
Review of the intracellular pathway of TREM‐1 signaling, its interactions with PRR pathways, focusing on TLRs and NLRs. TREM‐1 is an important signaling receptor expressed on neutrophils and monocytes that plays an important role in systemic infections. Here, we review the intracellular signaling pa...
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| Veröffentlicht in: | Journal of leukocyte biology 2013-02, Vol.93 (2), p.209-215 |
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| container_title | Journal of leukocyte biology |
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| creator | Arts, Rob J. W. Joosten, Leo A. B. Meer, Jos W. M. Netea, Mihai G. |
| description | Review of the intracellular pathway of TREM‐1 signaling, its interactions with PRR pathways, focusing on TLRs and NLRs.
TREM‐1 is an important signaling receptor expressed on neutrophils and monocytes that plays an important role in systemic infections. Here, we review the intracellular signaling pathways that mediate the immunological effects of TREM‐1. Because of the absence of signaling motifs, TREM‐1 constitutively associates with DAP12 for induction of intracellular signals. After phosphorylation of DAP12, production of chemokines and cytokines is induced. Moreover, TREM‐1 also modulates signaling pathways induced by known classes of PRRs, such as TLRs and NLRs. The exact mechanisms through which TREM‐1 influences TLR and NLR pathways are still largely elusive. |
| doi_str_mv | 10.1189/jlb.0312145 |
| format | Article |
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TREM‐1 is an important signaling receptor expressed on neutrophils and monocytes that plays an important role in systemic infections. Here, we review the intracellular signaling pathways that mediate the immunological effects of TREM‐1. Because of the absence of signaling motifs, TREM‐1 constitutively associates with DAP12 for induction of intracellular signals. After phosphorylation of DAP12, production of chemokines and cytokines is induced. Moreover, TREM‐1 also modulates signaling pathways induced by known classes of PRRs, such as TLRs and NLRs. The exact mechanisms through which TREM‐1 influences TLR and NLR pathways are still largely elusive.</description><subject>Animals</subject><subject>DAP12</subject><subject>Humans</subject><subject>Membrane Glycoproteins - immunology</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>myeloid cells</subject><subject>NLR</subject><subject>Receptors, Immunologic - immunology</subject><subject>Receptors, Immunologic - metabolism</subject><subject>Receptors, Pattern Recognition - immunology</subject><subject>Receptors, Pattern Recognition - metabolism</subject><subject>Signal Transduction - immunology</subject><subject>signaling cascade</subject><subject>TLR</subject><subject>Triggering Receptor Expressed on Myeloid Cells-1</subject><issn>0741-5400</issn><issn>1938-3673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P4zAQhi20KyhdTtxRLkgrocDYTvzBDRAfi4qQVuxpD5bjOK2RmxQ7VdR_vw4tHNnLzGjmmXc0L0LHGM4xFvLi1VfnQDHBRbmHJlhSkVPG6Tc0AV7gvCwADtBhjK8AQAmDfXRAKAYBkk_Q35fft085vsxc2wdtrPdrr0MW3bzV3rXzbKX7xaA3MdNtPUI2Ub3r2mxw_WKcpk6bBWu6eeveB6m2q74L8Qf63mgf7dEuT9Gfu9uXm4d89nz_6-Zqlhsqqcw5gcJUopamJpJiI2psRSlZzUzVWEYa3lSVJIxKzUtRAieUUVuQpqmZMBWjU_Rzq7sK3dvaxl4tXRxf0a3t1lHhssSMcMHg_ygRlFPCU5iisy1qQhdjsI1aBbfUYaMwqNF4lYxXO-MTfbITXldLW3-yH04nALbA4LzdfKWlHmfXQECmldPtysLNF4MLVsWl9j5dIGoYBkkVUSP3D4g7mkk</recordid><startdate>201302</startdate><enddate>201302</enddate><creator>Arts, Rob J. 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W.</creatorcontrib><creatorcontrib>Joosten, Leo A. B.</creatorcontrib><creatorcontrib>Meer, Jos W. M.</creatorcontrib><creatorcontrib>Netea, Mihai G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of leukocyte biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arts, Rob J. W.</au><au>Joosten, Leo A. B.</au><au>Meer, Jos W. M.</au><au>Netea, Mihai G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors</atitle><jtitle>Journal of leukocyte biology</jtitle><addtitle>J Leukoc Biol</addtitle><date>2013-02</date><risdate>2013</risdate><volume>93</volume><issue>2</issue><spage>209</spage><epage>215</epage><pages>209-215</pages><issn>0741-5400</issn><eissn>1938-3673</eissn><abstract>Review of the intracellular pathway of TREM‐1 signaling, its interactions with PRR pathways, focusing on TLRs and NLRs.
TREM‐1 is an important signaling receptor expressed on neutrophils and monocytes that plays an important role in systemic infections. Here, we review the intracellular signaling pathways that mediate the immunological effects of TREM‐1. Because of the absence of signaling motifs, TREM‐1 constitutively associates with DAP12 for induction of intracellular signals. After phosphorylation of DAP12, production of chemokines and cytokines is induced. Moreover, TREM‐1 also modulates signaling pathways induced by known classes of PRRs, such as TLRs and NLRs. The exact mechanisms through which TREM‐1 influences TLR and NLR pathways are still largely elusive.</abstract><cop>United States</cop><pub>Society for Leukocyte Biology</pub><pmid>23108097</pmid><doi>10.1189/jlb.0312145</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of leukocyte biology, 2013-02, Vol.93 (2), p.209-215 |
| issn | 0741-5400 1938-3673 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals DAP12 Humans Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism myeloid cells NLR Receptors, Immunologic - immunology Receptors, Immunologic - metabolism Receptors, Pattern Recognition - immunology Receptors, Pattern Recognition - metabolism Signal Transduction - immunology signaling cascade TLR Triggering Receptor Expressed on Myeloid Cells-1 |
| title | TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors |
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