Indication for CDKN2A-mutation analysis in familial pancreatic cancer families without melanomas

BackgroundCDKN2A-mutation carriers run a high risk of developing melanomas and have an increased risk of developing pancreatic cancer (PC). Familial PC (FPC) patients with a personal history or family history of melanomas are therefore offered CDKN2A-mutation analysis. In contrast, CDKN2A testing in...

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Veröffentlicht in:	Journal of medical genetics 2012-06, Vol.49 (6), p.362-365
Hauptverfasser:	Harinck, Femme, Kluijt, Irma, van der Stoep, Nienke, Oldenburg, Rogier A, Wagner, Anja, Aalfs, Cora M, Sijmons, Rolf H, Poley, Jan-Werner, Kuipers, Ernst J, Fockens, Paul, van Os, Theo A M, Bruno, Marco J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences cancer prevention cancer susceptibility cancer: dermatological Cyclin-Dependent Kinase Inhibitor p16 - genetics diagnosis diagnostics tests Female Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen genetic screening/counselling Genetics of eukaryotes. Biological and molecular evolution Humans inherited cancer Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical genetics Medical sciences Melanoma - genetics Middle Aged Molecular and cellular biology Mutation mutations Pancreatic cancer Pancreatic Neoplasms - genetics prevention Retrospective Studies Sequence Analysis, DNA Tumors
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