Cryptococcus gattii is killed by dendritic cells, but evades adaptive immunity by failing to induce dendritic cell maturation

During adaptive immunity to pathogens, dendritic cells (DCs) capture, kill, process, and present microbial Ags to T cells. Ag presentation is accompanied by DC maturation driven by appropriate costimulatory signals. However, current understanding of the intricate regulation of these processes remain...

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Veröffentlicht in:	The Journal of immunology (1950) 2013-07, Vol.191 (1), p.249-261
Hauptverfasser:	Huston, Shaunna M, Li, Shu Shun, Stack, Danuta, Timm-McCann, Martina, Jones, Gareth J, Islam, Anowara, Berenger, Byron M, Xiang, Richard F, Colarusso, Pina, Mody, Christopher H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity - immunology Cell Differentiation - immunology Cells, Cultured Cryptococcosis - immunology Cryptococcosis - microbiology Cryptococcosis - pathology Cryptococcus Cryptococcus gattii - growth & development Cryptococcus gattii - immunology Cryptococcus gattii - pathogenicity Dendritic Cells - immunology Dendritic Cells - microbiology Dendritic Cells - pathology Humans Immune Evasion - immunology Immunophenotyping Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - physiology
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