Cutting edge: a novel mechanism bridging innate and adaptive immunity: IL-12 induction of CD25 to form high-affinity IL-2 receptors on NK cells

NK cell expression and use of the IL-2Rα-chain (CD25), required for the high-affinity IL-2R, remain poorly understood. The studies reported in this article demonstrate that infections with murine CMV (MCMV), but not with lymphocytic choriomeningitis virus, induce CD25 on NK cells, along with high le...

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Veröffentlicht in:	The Journal of immunology (1950) 2012-09, Vol.189 (6), p.2712-2716
Hauptverfasser:	Lee, Seung-Hwan, Fragoso, Maria F, Biron, Christine A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Animals Cell Line Cells, Cultured Humans Immunity, Innate Interleukin-12 - physiology Interleukin-2 Receptor alpha Subunit - biosynthesis Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Killer Cells, Natural - virology Lymphocytic choriomeningitis virus Lymphocytic choriomeningitis virus - immunology Mice Mice, Inbred C57BL Mice, Knockout Murine cytomegalovirus Muromegalovirus - immunology Protein Binding - immunology Receptors, Interleukin-2 - biosynthesis Receptors, Interleukin-2 - metabolism
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