B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by the production of antinuclear autoantibodies. Antinuclear autoantibody development is recognized as one of the initial stages of disease that often results in systemic inflammation, kidney disease, and death...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2012-12, Vol.189 (12), p.5786-5796
Hauptverfasser:	Hwang, Sun-Hee, Lee, Huiyin, Yamamoto, Miwako, Jones, Leigh A, Dayalan, Jivanaah, Hopkins, Richard, Zhou, Xin J, Yarovinsky, Felix, Connolly, John E, Curotto de Lafaille, Maria A, Wakeland, Edward K, Fairhurst, Anna-Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantibodies - adverse effects Autoantibodies - biosynthesis B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - metabolism B-Lymphocyte Subsets - pathology Disease Progression Epistasis, Genetic - immunology Female Gene Expression Regulation, Developmental - immunology Genetic Predisposition to Disease Humans Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology Male Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Membrane Glycoproteins - physiology Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Transgenic Multiprotein Complexes - genetics Multiprotein Complexes - immunology Toll-Like Receptor 7 - biosynthesis Toll-Like Receptor 7 - genetics Toll-Like Receptor 7 - physiology Transgenes - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!