α 2 δ-1 Gene Deletion Affects Somatosensory Neuron Function and Delays Mechanical Hypersensitivity in Response to Peripheral Nerve Damage

The α 2 δ-1 subunit of voltage-gated calcium channels is upregulated after sensory nerve injury and is also the therapeutic target of gabapentinoid drugs. It is therefore likely to play a key role in the development of neuropathic pain. In this study, we have examined mice in which α 2 δ-1 gene expr...

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Veröffentlicht in:	The Journal of neuroscience 2013-10, Vol.33 (42), p.16412-16426
Hauptverfasser:	Patel, Ryan, Bauer, Claudia S., Nieto-Rostro, Manuela, Margas, Wojciech, Ferron, Laurent, Chaggar, Kanchan, Crews, Kasumi, Ramirez, Juan D., Bennett, David L. H., Schwartz, Arnold, Dickenson, Anthony H., Dolphin, Annette C.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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