CD26/DPP4 Levels in Peripheral Blood and T Cells in Patients With Type 2 Diabetes Mellitus
Context: Dipeptidyl peptidase 4 (CD26/DPP4) is expressed on blood T cells and also circulates in a soluble form (sCD26/DPP4). Objective: We aimed to evaluate blood T cell and circulating CD26/DPP4 and its association with metabolic parameters in patients with type 2 diabetes mellitus (T2DM). Designs...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2013-06, Vol.98 (6), p.2553-2561 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | Lee, Sang Ah Kim, Young Ree Yang, Eun Jin Kwon, Eun-Jeong Kim, Sun Hyung Kang, Sung Ha Park, Doek Bae Oh, Byung-Chul Kim, Jinseok Heo, Sang Taek Koh, Gwanpyo Lee, Dae Ho |
| description | Context:
Dipeptidyl peptidase 4 (CD26/DPP4) is expressed on blood T cells and also circulates in a soluble form (sCD26/DPP4).
Objective:
We aimed to evaluate blood T cell and circulating CD26/DPP4 and its association with metabolic parameters in patients with type 2 diabetes mellitus (T2DM).
Designs:
We measured CD26/DPP4 expression (percentage of CD26+ cells using flow cytometry) on CD4+ and CD8+ T cells, serum CD26/DPP4 level and activity, and various metabolic parameters in T2DM patients not on DPP4 inhibitor therapy (n = 148). Nondiabetic subjects (n = 50) were included as a control group.
Results:
Compared with the healthy controls, CD26/DPP4 expression on CD4+ T cells and CD8+ T cells was higher in T2DM patients. Serum CD26/DPP4 levels and enzymatic activities were also higher in patients with T2DM than in the control group only when metformin and/or thiazolidinedione-treated T2DM patients were excluded; metformin and/or thiazolidinedione-treated T2DM patients had lower values compared with other T2DM patients. Various parameters in T2DM patients were related to CD26/DPP4 expression on the T cells (hemoglobin A1c), serum sCD26/DPP4 (hemoglobin A1c and insulin resistance assessed by updated homeostasis model assessment), and serum CD26/DPP4 activity (insulin resistance assessed by updated homeostasis model assessment, γ-glutamyl transferase, and alanine aminotransferase) by multivariate analyses. After active glucose control for 12 weeks in drug-naive T2DM patients (n = 50), CD26/DPP4 expression on blood T cells was significantly decreased.
Conclusions:
Our results suggest that the CD26/DPP4 level on blood T cells was associated with glucose control status in patients with T2DM. |
| doi_str_mv | 10.1210/jc.2012-4288 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1551625158</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1210/jc.2012-4288</oup_id><sourcerecordid>1551625158</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5417-c9d8e07f9fa9148427959a86873ce10896c160141c254ddc105dfcd1f935d6233</originalsourceid><addsrcrecordid>eNqF0c2L1DAUAPAgiju7evMsARE92N18fxx1xi8YcQ4jipeQTV-Zjp22m7S77H9vSkcXRDGXkOSXl_fyEHpCyTlllFzswzkjlBWCGXMPLagVstDU6vtoQQijhdXs2wk6TWlPCBVC8ofohHHJreZygb4vV0xdrDYbgddwDU3CdYs3EOt-B9E3-E3TdSX2bYm3eAnN8dwPNbRDwl_rYYe3tz1ghle1v4QBEv6UWT2M6RF6UPkmwePjfIa-vHu7XX4o1p_ff1y-XhdBCqqLYEsDRFe28pYKI5i20nqjjOYBKDFWBapy5jQwKcoyUCLLKpS0slyWinF-hl7OcfvYXY2QBneoU8hJ-Ba6MTkqJVVMUmn-T7kSmljOdKbP_qD7boxtLsRxqoRQIv90Vq9mFWKXUoTK9bE--HjrKHFTe9w-uKk9bmpP5k-PQcfLA5S_8a9-ZPD8CHwKvqmib0Od7pzOzBqVnZjdTdcMENOPZryB6Hbgm2HnSB5CaVPklzlReVVMO1NRL-Zr3dj_K9PimCmfJbRlF2LdQh8hpbtP-Gt9PwFXB78X</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3164464194</pqid></control><display><type>article</type><title>CD26/DPP4 Levels in Peripheral Blood and T Cells in Patients With Type 2 Diabetes Mellitus</title><source>Journals@Ovid Ovid Autoload</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Lee, Sang Ah ; Kim, Young Ree ; Yang, Eun Jin ; Kwon, Eun-Jeong ; Kim, Sun Hyung ; Kang, Sung Ha ; Park, Doek Bae ; Oh, Byung-Chul ; Kim, Jinseok ; Heo, Sang Taek ; Koh, Gwanpyo ; Lee, Dae Ho</creator><creatorcontrib>Lee, Sang Ah ; Kim, Young Ree ; Yang, Eun Jin ; Kwon, Eun-Jeong ; Kim, Sun Hyung ; Kang, Sung Ha ; Park, Doek Bae ; Oh, Byung-Chul ; Kim, Jinseok ; Heo, Sang Taek ; Koh, Gwanpyo ; Lee, Dae Ho</creatorcontrib><description>Context:
Dipeptidyl peptidase 4 (CD26/DPP4) is expressed on blood T cells and also circulates in a soluble form (sCD26/DPP4).
Objective:
We aimed to evaluate blood T cell and circulating CD26/DPP4 and its association with metabolic parameters in patients with type 2 diabetes mellitus (T2DM).
Designs:
We measured CD26/DPP4 expression (percentage of CD26+ cells using flow cytometry) on CD4+ and CD8+ T cells, serum CD26/DPP4 level and activity, and various metabolic parameters in T2DM patients not on DPP4 inhibitor therapy (n = 148). Nondiabetic subjects (n = 50) were included as a control group.
Results:
Compared with the healthy controls, CD26/DPP4 expression on CD4+ T cells and CD8+ T cells was higher in T2DM patients. Serum CD26/DPP4 levels and enzymatic activities were also higher in patients with T2DM than in the control group only when metformin and/or thiazolidinedione-treated T2DM patients were excluded; metformin and/or thiazolidinedione-treated T2DM patients had lower values compared with other T2DM patients. Various parameters in T2DM patients were related to CD26/DPP4 expression on the T cells (hemoglobin A1c), serum sCD26/DPP4 (hemoglobin A1c and insulin resistance assessed by updated homeostasis model assessment), and serum CD26/DPP4 activity (insulin resistance assessed by updated homeostasis model assessment, γ-glutamyl transferase, and alanine aminotransferase) by multivariate analyses. After active glucose control for 12 weeks in drug-naive T2DM patients (n = 50), CD26/DPP4 expression on blood T cells was significantly decreased.
Conclusions:
Our results suggest that the CD26/DPP4 level on blood T cells was associated with glucose control status in patients with T2DM.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2012-4288</identifier><identifier>PMID: 23539735</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adult ; Alanine transaminase ; Biological and medical sciences ; Blood Glucose - analysis ; Blood levels ; CD4 antigen ; CD8 antigen ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - enzymology ; Diabetes. Impaired glucose tolerance ; Dipeptidyl Peptidase 4 - blood ; Dipeptidyl-peptidase IV ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Enzymatic activity ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Feeding. Feeding behavior ; Female ; Flow cytometry ; Fundamental and applied biological sciences. Psychology ; Hemoglobin ; Homeostasis ; Humans ; Insulin resistance ; Lymphocytes ; Lymphocytes T ; Male ; Medical sciences ; Metabolism ; Metformin ; Metformin - therapeutic use ; Middle Aged ; Peripheral blood ; T-Lymphocytes - enzymology ; Thiazolidinediones - therapeutic use ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology</subject><ispartof>The journal of clinical endocrinology and metabolism, 2013-06, Vol.98 (6), p.2553-2561</ispartof><rights>Copyright © 2013 by The Endocrine Society</rights><rights>Copyright © 2013 by The Endocrine Society 2013</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5417-c9d8e07f9fa9148427959a86873ce10896c160141c254ddc105dfcd1f935d6233</citedby><cites>FETCH-LOGICAL-c5417-c9d8e07f9fa9148427959a86873ce10896c160141c254ddc105dfcd1f935d6233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27397986$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23539735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Sang Ah</creatorcontrib><creatorcontrib>Kim, Young Ree</creatorcontrib><creatorcontrib>Yang, Eun Jin</creatorcontrib><creatorcontrib>Kwon, Eun-Jeong</creatorcontrib><creatorcontrib>Kim, Sun Hyung</creatorcontrib><creatorcontrib>Kang, Sung Ha</creatorcontrib><creatorcontrib>Park, Doek Bae</creatorcontrib><creatorcontrib>Oh, Byung-Chul</creatorcontrib><creatorcontrib>Kim, Jinseok</creatorcontrib><creatorcontrib>Heo, Sang Taek</creatorcontrib><creatorcontrib>Koh, Gwanpyo</creatorcontrib><creatorcontrib>Lee, Dae Ho</creatorcontrib><title>CD26/DPP4 Levels in Peripheral Blood and T Cells in Patients With Type 2 Diabetes Mellitus</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Context:
Dipeptidyl peptidase 4 (CD26/DPP4) is expressed on blood T cells and also circulates in a soluble form (sCD26/DPP4).
Objective:
We aimed to evaluate blood T cell and circulating CD26/DPP4 and its association with metabolic parameters in patients with type 2 diabetes mellitus (T2DM).
Designs:
We measured CD26/DPP4 expression (percentage of CD26+ cells using flow cytometry) on CD4+ and CD8+ T cells, serum CD26/DPP4 level and activity, and various metabolic parameters in T2DM patients not on DPP4 inhibitor therapy (n = 148). Nondiabetic subjects (n = 50) were included as a control group.
Results:
Compared with the healthy controls, CD26/DPP4 expression on CD4+ T cells and CD8+ T cells was higher in T2DM patients. Serum CD26/DPP4 levels and enzymatic activities were also higher in patients with T2DM than in the control group only when metformin and/or thiazolidinedione-treated T2DM patients were excluded; metformin and/or thiazolidinedione-treated T2DM patients had lower values compared with other T2DM patients. Various parameters in T2DM patients were related to CD26/DPP4 expression on the T cells (hemoglobin A1c), serum sCD26/DPP4 (hemoglobin A1c and insulin resistance assessed by updated homeostasis model assessment), and serum CD26/DPP4 activity (insulin resistance assessed by updated homeostasis model assessment, γ-glutamyl transferase, and alanine aminotransferase) by multivariate analyses. After active glucose control for 12 weeks in drug-naive T2DM patients (n = 50), CD26/DPP4 expression on blood T cells was significantly decreased.
Conclusions:
Our results suggest that the CD26/DPP4 level on blood T cells was associated with glucose control status in patients with T2DM.</description><subject>Adult</subject><subject>Alanine transaminase</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Blood levels</subject><subject>CD4 antigen</subject><subject>CD8 antigen</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - enzymology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Dipeptidyl Peptidase 4 - blood</subject><subject>Dipeptidyl-peptidase IV</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Enzymatic activity</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemoglobin</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Metformin</subject><subject>Metformin - therapeutic use</subject><subject>Middle Aged</subject><subject>Peripheral blood</subject><subject>T-Lymphocytes - enzymology</subject><subject>Thiazolidinediones - therapeutic use</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c2L1DAUAPAgiju7evMsARE92N18fxx1xi8YcQ4jipeQTV-Zjp22m7S77H9vSkcXRDGXkOSXl_fyEHpCyTlllFzswzkjlBWCGXMPLagVstDU6vtoQQijhdXs2wk6TWlPCBVC8ofohHHJreZygb4vV0xdrDYbgddwDU3CdYs3EOt-B9E3-E3TdSX2bYm3eAnN8dwPNbRDwl_rYYe3tz1ghle1v4QBEv6UWT2M6RF6UPkmwePjfIa-vHu7XX4o1p_ff1y-XhdBCqqLYEsDRFe28pYKI5i20nqjjOYBKDFWBapy5jQwKcoyUCLLKpS0slyWinF-hl7OcfvYXY2QBneoU8hJ-Ba6MTkqJVVMUmn-T7kSmljOdKbP_qD7boxtLsRxqoRQIv90Vq9mFWKXUoTK9bE--HjrKHFTe9w-uKk9bmpP5k-PQcfLA5S_8a9-ZPD8CHwKvqmib0Od7pzOzBqVnZjdTdcMENOPZryB6Hbgm2HnSB5CaVPklzlReVVMO1NRL-Zr3dj_K9PimCmfJbRlF2LdQh8hpbtP-Gt9PwFXB78X</recordid><startdate>201306</startdate><enddate>201306</enddate><creator>Lee, Sang Ah</creator><creator>Kim, Young Ree</creator><creator>Yang, Eun Jin</creator><creator>Kwon, Eun-Jeong</creator><creator>Kim, Sun Hyung</creator><creator>Kang, Sung Ha</creator><creator>Park, Doek Bae</creator><creator>Oh, Byung-Chul</creator><creator>Kim, Jinseok</creator><creator>Heo, Sang Taek</creator><creator>Koh, Gwanpyo</creator><creator>Lee, Dae Ho</creator><general>Endocrine Society</general><general>Oxford University Press</general><general>Copyright by The Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201306</creationdate><title>CD26/DPP4 Levels in Peripheral Blood and T Cells in Patients With Type 2 Diabetes Mellitus</title><author>Lee, Sang Ah ; Kim, Young Ree ; Yang, Eun Jin ; Kwon, Eun-Jeong ; Kim, Sun Hyung ; Kang, Sung Ha ; Park, Doek Bae ; Oh, Byung-Chul ; Kim, Jinseok ; Heo, Sang Taek ; Koh, Gwanpyo ; Lee, Dae Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5417-c9d8e07f9fa9148427959a86873ce10896c160141c254ddc105dfcd1f935d6233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Alanine transaminase</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Blood levels</topic><topic>CD4 antigen</topic><topic>CD8 antigen</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - enzymology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Dipeptidyl Peptidase 4 - blood</topic><topic>Dipeptidyl-peptidase IV</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Enzymatic activity</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Flow cytometry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hemoglobin</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Insulin resistance</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Metformin</topic><topic>Metformin - therapeutic use</topic><topic>Middle Aged</topic><topic>Peripheral blood</topic><topic>T-Lymphocytes - enzymology</topic><topic>Thiazolidinediones - therapeutic use</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Sang Ah</creatorcontrib><creatorcontrib>Kim, Young Ree</creatorcontrib><creatorcontrib>Yang, Eun Jin</creatorcontrib><creatorcontrib>Kwon, Eun-Jeong</creatorcontrib><creatorcontrib>Kim, Sun Hyung</creatorcontrib><creatorcontrib>Kang, Sung Ha</creatorcontrib><creatorcontrib>Park, Doek Bae</creatorcontrib><creatorcontrib>Oh, Byung-Chul</creatorcontrib><creatorcontrib>Kim, Jinseok</creatorcontrib><creatorcontrib>Heo, Sang Taek</creatorcontrib><creatorcontrib>Koh, Gwanpyo</creatorcontrib><creatorcontrib>Lee, Dae Ho</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Sang Ah</au><au>Kim, Young Ree</au><au>Yang, Eun Jin</au><au>Kwon, Eun-Jeong</au><au>Kim, Sun Hyung</au><au>Kang, Sung Ha</au><au>Park, Doek Bae</au><au>Oh, Byung-Chul</au><au>Kim, Jinseok</au><au>Heo, Sang Taek</au><au>Koh, Gwanpyo</au><au>Lee, Dae Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD26/DPP4 Levels in Peripheral Blood and T Cells in Patients With Type 2 Diabetes Mellitus</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2013-06</date><risdate>2013</risdate><volume>98</volume><issue>6</issue><spage>2553</spage><epage>2561</epage><pages>2553-2561</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Context:
Dipeptidyl peptidase 4 (CD26/DPP4) is expressed on blood T cells and also circulates in a soluble form (sCD26/DPP4).
Objective:
We aimed to evaluate blood T cell and circulating CD26/DPP4 and its association with metabolic parameters in patients with type 2 diabetes mellitus (T2DM).
Designs:
We measured CD26/DPP4 expression (percentage of CD26+ cells using flow cytometry) on CD4+ and CD8+ T cells, serum CD26/DPP4 level and activity, and various metabolic parameters in T2DM patients not on DPP4 inhibitor therapy (n = 148). Nondiabetic subjects (n = 50) were included as a control group.
Results:
Compared with the healthy controls, CD26/DPP4 expression on CD4+ T cells and CD8+ T cells was higher in T2DM patients. Serum CD26/DPP4 levels and enzymatic activities were also higher in patients with T2DM than in the control group only when metformin and/or thiazolidinedione-treated T2DM patients were excluded; metformin and/or thiazolidinedione-treated T2DM patients had lower values compared with other T2DM patients. Various parameters in T2DM patients were related to CD26/DPP4 expression on the T cells (hemoglobin A1c), serum sCD26/DPP4 (hemoglobin A1c and insulin resistance assessed by updated homeostasis model assessment), and serum CD26/DPP4 activity (insulin resistance assessed by updated homeostasis model assessment, γ-glutamyl transferase, and alanine aminotransferase) by multivariate analyses. After active glucose control for 12 weeks in drug-naive T2DM patients (n = 50), CD26/DPP4 expression on blood T cells was significantly decreased.
Conclusions:
Our results suggest that the CD26/DPP4 level on blood T cells was associated with glucose control status in patients with T2DM.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>23539735</pmid><doi>10.1210/jc.2012-4288</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The journal of clinical endocrinology and metabolism, 2013-06, Vol.98 (6), p.2553-2561 |
| issn | 0021-972X 1945-7197 |
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| recordid | cdi_proquest_miscellaneous_1551625158 |
| source | Journals@Ovid Ovid Autoload; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Alanine transaminase Biological and medical sciences Blood Glucose - analysis Blood levels CD4 antigen CD8 antigen Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - enzymology Diabetes. Impaired glucose tolerance Dipeptidyl Peptidase 4 - blood Dipeptidyl-peptidase IV Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzymatic activity Etiopathogenesis. Screening. Investigations. Target tissue resistance Feeding. Feeding behavior Female Flow cytometry Fundamental and applied biological sciences. Psychology Hemoglobin Homeostasis Humans Insulin resistance Lymphocytes Lymphocytes T Male Medical sciences Metabolism Metformin Metformin - therapeutic use Middle Aged Peripheral blood T-Lymphocytes - enzymology Thiazolidinediones - therapeutic use Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| title | CD26/DPP4 Levels in Peripheral Blood and T Cells in Patients With Type 2 Diabetes Mellitus |
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