Inhibition of phagocytosis reduced the classical activation of BV2 microglia induced by amyloidogenic fragments of beta-amyloid and prion proteins

The inflammatory responses in Alzheimer's disease and prion diseases are dominated by microglia activation. Three different phenotypes of microglial activation, namely classical activation, alternative activation, and acquired deactivation, have been described. In this study, we investigated the eff...

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Veröffentlicht in:Acta biochimica et biophysica Sinica 2013-11, Vol.45 (11), p.973-978
Hauptverfasser: Shi, Fushan, Yang, Lifeng, Wang, Jihong, Kouadir, Mohammed, Yang, Yang, Fu, Yongyao, Zhou, Xiangmei, Yin, Xiaomin, Zhao, Deming
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Sprache:eng
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