Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury
A review of mechanisms of apoptosis induction in influenza virus‐infected cells, and the impact of apoptotic signaling on viral propagation, immune responses, and tissue injury. Programmed cell death is a crucial cellular response frequently observed in IV‐infected tissue. This article reviews the c...
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| Veröffentlicht in: | Journal of leukocyte biology 2012-07, Vol.92 (1), p.75-82 |
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| container_title | Journal of leukocyte biology |
| container_volume | 92 |
| creator | Herold, Susanne Ludwig, Stephan Pleschka, Stephan Wolff, Thorsten |
| description | A review of mechanisms of apoptosis induction in influenza virus‐infected cells, and the impact of apoptotic signaling on viral propagation, immune responses, and tissue injury.
Programmed cell death is a crucial cellular response frequently observed in IV‐infected tissue. This article reviews the current knowledge on the molecular virus–host interactions that induce apoptosis pathways in an IV‐infected cell and the functional implications of these cellular signaling events on viral propagation at distinct steps during the viral replication cycle. Furthermore, it summarizes the role of IV‐induced apoptosis pathways in equilibrating the hostˈs antiviral immune response between effective viral clearance and development of severe apoptotic lung injury. |
| doi_str_mv | 10.1189/jlb.1011530 |
| format | Article |
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Programmed cell death is a crucial cellular response frequently observed in IV‐infected tissue. This article reviews the current knowledge on the molecular virus–host interactions that induce apoptosis pathways in an IV‐infected cell and the functional implications of these cellular signaling events on viral propagation at distinct steps during the viral replication cycle. Furthermore, it summarizes the role of IV‐induced apoptosis pathways in equilibrating the hostˈs antiviral immune response between effective viral clearance and development of severe apoptotic lung injury.</description><identifier>ISSN: 0741-5400</identifier><identifier>EISSN: 1938-3673</identifier><identifier>DOI: 10.1189/jlb.1011530</identifier><identifier>PMID: 22345705</identifier><language>eng</language><publisher>United States: Society for Leukocyte Biology</publisher><subject>Apoptosis ; ARDS ; Humans ; Immunity, Innate ; Influenza virus ; Influenza, Human - immunology ; Influenza, Human - pathology ; Influenza, Human - virology ; Lung Injury ; NS1 ; Orthomyxoviridae - pathogenicity ; PB1‐F2 ; replication ; TRAIL ; viral ; Virus Replication</subject><ispartof>Journal of leukocyte biology, 2012-07, Vol.92 (1), p.75-82</ispartof><rights>2012 Society for Leukocyte Biology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4295-4bee3e9ba30797a65fc51b006ebb6833d858711bc960411dea1e47930bc3b6463</citedby><cites>FETCH-LOGICAL-c4295-4bee3e9ba30797a65fc51b006ebb6833d858711bc960411dea1e47930bc3b6463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1189%2Fjlb.1011530$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1189%2Fjlb.1011530$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22345705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herold, Susanne</creatorcontrib><creatorcontrib>Ludwig, Stephan</creatorcontrib><creatorcontrib>Pleschka, Stephan</creatorcontrib><creatorcontrib>Wolff, Thorsten</creatorcontrib><title>Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury</title><title>Journal of leukocyte biology</title><addtitle>J Leukoc Biol</addtitle><description>A review of mechanisms of apoptosis induction in influenza virus‐infected cells, and the impact of apoptotic signaling on viral propagation, immune responses, and tissue injury.
Programmed cell death is a crucial cellular response frequently observed in IV‐infected tissue. This article reviews the current knowledge on the molecular virus–host interactions that induce apoptosis pathways in an IV‐infected cell and the functional implications of these cellular signaling events on viral propagation at distinct steps during the viral replication cycle. Furthermore, it summarizes the role of IV‐induced apoptosis pathways in equilibrating the hostˈs antiviral immune response between effective viral clearance and development of severe apoptotic lung injury.</description><subject>Apoptosis</subject><subject>ARDS</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Influenza virus</subject><subject>Influenza, Human - immunology</subject><subject>Influenza, Human - pathology</subject><subject>Influenza, Human - virology</subject><subject>Lung Injury</subject><subject>NS1</subject><subject>Orthomyxoviridae - pathogenicity</subject><subject>PB1‐F2</subject><subject>replication</subject><subject>TRAIL</subject><subject>viral</subject><subject>Virus Replication</subject><issn>0741-5400</issn><issn>1938-3673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2P0zAQhi0EYsvCiTvKgQMSm2X8mfi4u2L5UCUuIHGz7GTSunKdECcblV-PSwtHkCzNwc_7zugh5CWFa0pr_W4X3DUFSiWHR2RFNa9Lrir-mKygErSUAuCCPEtpBwCcKXhKLhjjQlYgV-T7zdAPU598KpLfRBt83BQ-5teFGeNPWzz4cU7FMPaD3djJ9_Eqf0Y7YbHt01S02GFMeFXY2BZh_p3ezePhOXnS2ZDwxXlekm_377_efSzXXz58urtZl41gWpbCIXLUznKodGWV7BpJHYBC51TNeVvLuqLUNVqBoLRFS1FUmoNruFNC8Uvy5tSbL_wxY5rM3qcGQ7AR-zkZKiVVTIha_x8FxmrFa3lE357QZuxTGrEzw-j3djxkyBytm2zdnK1n-tW5eHZ7bP-yfzRnAE7A4gMe_tVlPq9vAapj5PUpsvWb7eJHNGlvQ8gbmFmWRTNDTcZ-AXBHmGo</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Herold, Susanne</creator><creator>Ludwig, Stephan</creator><creator>Pleschka, Stephan</creator><creator>Wolff, Thorsten</creator><general>Society for Leukocyte Biology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7T5</scope><scope>7U2</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>20120701</creationdate><title>Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury</title><author>Herold, Susanne ; Ludwig, Stephan ; Pleschka, Stephan ; Wolff, Thorsten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4295-4bee3e9ba30797a65fc51b006ebb6833d858711bc960411dea1e47930bc3b6463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Apoptosis</topic><topic>ARDS</topic><topic>Humans</topic><topic>Immunity, Innate</topic><topic>Influenza virus</topic><topic>Influenza, Human - immunology</topic><topic>Influenza, Human - pathology</topic><topic>Influenza, Human - virology</topic><topic>Lung Injury</topic><topic>NS1</topic><topic>Orthomyxoviridae - pathogenicity</topic><topic>PB1‐F2</topic><topic>replication</topic><topic>TRAIL</topic><topic>viral</topic><topic>Virus Replication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herold, Susanne</creatorcontrib><creatorcontrib>Ludwig, Stephan</creatorcontrib><creatorcontrib>Pleschka, Stephan</creatorcontrib><creatorcontrib>Wolff, Thorsten</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Safety Science and Risk</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of leukocyte biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herold, Susanne</au><au>Ludwig, Stephan</au><au>Pleschka, Stephan</au><au>Wolff, Thorsten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury</atitle><jtitle>Journal of leukocyte biology</jtitle><addtitle>J Leukoc Biol</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>92</volume><issue>1</issue><spage>75</spage><epage>82</epage><pages>75-82</pages><issn>0741-5400</issn><eissn>1938-3673</eissn><abstract>A review of mechanisms of apoptosis induction in influenza virus‐infected cells, and the impact of apoptotic signaling on viral propagation, immune responses, and tissue injury.
Programmed cell death is a crucial cellular response frequently observed in IV‐infected tissue. This article reviews the current knowledge on the molecular virus–host interactions that induce apoptosis pathways in an IV‐infected cell and the functional implications of these cellular signaling events on viral propagation at distinct steps during the viral replication cycle. Furthermore, it summarizes the role of IV‐induced apoptosis pathways in equilibrating the hostˈs antiviral immune response between effective viral clearance and development of severe apoptotic lung injury.</abstract><cop>United States</cop><pub>Society for Leukocyte Biology</pub><pmid>22345705</pmid><doi>10.1189/jlb.1011530</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of leukocyte biology, 2012-07, Vol.92 (1), p.75-82 |
| issn | 0741-5400 1938-3673 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Apoptosis ARDS Humans Immunity, Innate Influenza virus Influenza, Human - immunology Influenza, Human - pathology Influenza, Human - virology Lung Injury NS1 Orthomyxoviridae - pathogenicity PB1‐F2 replication TRAIL viral Virus Replication |
| title | Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury |
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