Recycling endosome-dependent and -independent mechanisms for IL-10 secretion in LPS-activated macrophages

Two post‐Golgi pathways where IL‐10 is trafficked, ensures its secretion from activated macrophages under different physiological conditions. IL‐10 is a key anti‐inflammatory cytokine secreted by activated macrophages as a feedback control mechanism to prevent excessive inflammatory responses. Here,...

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Veröffentlicht in:	Journal of leukocyte biology 2012-12, Vol.92 (6), p.1227-1239
Hauptverfasser:	Stanley, A. C., Lieu, Z. Z., Wall, A. A., Venturato, J., Khromykh, T., Hamilton, N. A., Gleeson, P. A., Stow, J. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Membrane - immunology Cell Membrane - metabolism cytokines Cytokines - immunology Cytokines - metabolism Endosomes - metabolism Golgi Apparatus - metabolism Inflammation Mediators - immunology Inflammation Mediators - metabolism Interleukin-10 - biosynthesis Interleukin-10 - immunology Interleukin-6 - immunology Interleukin-6 - metabolism Lipopolysaccharides - immunology Macrophage Activation - immunology Macrophages - immunology Macrophages - metabolism Mice Protein Transport RNA Interference secretion trafficking Tumor Necrosis Factor-alpha Tumor Necrosis Factors - immunology Tumor Necrosis Factors - metabolism
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