G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis

G protein-coupled receptor kinases (GRKs) phosphorylate the activated form of G protein-coupled receptors leading to receptor desensitization and downregulation. We have recently shown that the chemokine receptor, CXCR2, couples to GRK6 to regulate cellular responses including chemotaxis, angiogenes...

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Veröffentlicht in:	The Journal of immunology (1950) 2013-05, Vol.190 (10), p.5329-5336
Hauptverfasser:	Raghuwanshi, Sandeep K, Smith, Nikia, Rivers, Elizabeth J, Thomas, Ariel J, Sutton, Natalie, Hu, Yuhui, Mukhopadhyay, Somnath, Chen, Xiaoxin L, Leung, TinChung, Richardson, Ricardo M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrestins - deficiency Arrestins - genetics Arrestins - metabolism beta-Arrestin 2 beta-Arrestins Carcinoma, Lewis Lung - metabolism Cell Line, Tumor Chemotaxis Disease Progression Down-Regulation G-Protein-Coupled Receptor Kinases - deficiency G-Protein-Coupled Receptor Kinases - genetics G-Protein-Coupled Receptor Kinases - metabolism Genotype Lung Neoplasms - metabolism Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 9 - biosynthesis Mice Mice, Knockout Neoplasm Metastasis Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neutrophils - immunology Phenylurea Compounds - pharmacology Phosphorylation Receptors, Interleukin-8B - antagonists & inhibitors Receptors, Interleukin-8B - metabolism Signal Transduction Tumor Microenvironment Up-Regulation Wound Healing
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